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,C6H11NO2,129.1601,4-amino-5-hexenoic acid

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摘 要:,C6H11NO2,129.1601,4-amino-5-hexenoic acid
  • 【化学名】4-amino-5-hexenoic acid
  • 【CAS登记号】
  • 【结构式】,C6H11NO2,129.1601,4-amino-5-hexenoic acid--药物合成数据库
  • 【分子式】C6H11NO2
  • 【分子量】129.1601
  • 【来源】A.G. Scientific; Tocris Cookson Ltd.
  • 【合成情况】 
  • 〖目标产物〗
  • 〖合成路线〗
  • 〖合成方法〗Boc-protected vigabatrin (II) was prepared from vigabatrin (I) by treatment with 2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile. Coupling of the protected vigabatrin (II) with methyl nipecotate (III) in the presence of EDC and HOBt afforded the corresponding amide (IV). The Boc protecting group of (IV) was finally cleaved by treatment with trifluoroacetic acid.
  • 〖参考〗Zhao, L.-X.; Kim, T.-H.; Kim, Y.; et al.; Design and synthesis of anticonvulsive agents as gamma-Vinyl GABA-based potential dual acting prodrugs and their biological activities. Bioorg Med Chem Lett 2000, 10, 7, 609
 
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