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Enalapril maleate, MK-421, Ednit, Ditensor, Dabonal, Baripri

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摘 要:Enalapril maleate, MK-421, Ednit, Ditensor, Dabonal, Baripril, Crinoren, Xanef, Renitec, Enapren, Innovace, Innovace Melt(freeze-dried oral wafer), Lexxel(comb. with felodipine), Renivace, Vasotec,76095-16-4, 75847-73-3 (free base),C20-H28-N2-O5.C4-H
  • 【药物名称】Enalapril maleate, MK-421, Ednit, Ditensor, Dabonal, Baripril, Crinoren, Xanef, Renitec, Enapren, Innovace, Innovace Melt(freeze-dried oral wafer), Lexxel(comb. with felodipine), Renivace, Vasotec
  • 【化学名】(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline maleate
  • 【CAS登记号】76095-16-4, 75847-73-3 (free base)
  • 【结构式】Enalapril maleate, MK-421, Ednit, Ditensor, Dabonal, Baripri--药物合成数据库
  • 【分子式】C20-H28-N2-O5.C4-H4-O4
  • 【分子量】492.5218
  • 【原研厂家】Merck & Co. (Originator), Merck Sharp & Dohme (Originator), Almirall Prodesfarma (Licensee), Banyu (Licensee), Uriach (Licensee), Vita (Licensee)
  • 【作用类别】CARDIOVASCULAR DRUGS, Heart Failure Therapy, Hypertension, Treatment of, OCULAR MEDICATIONS, Ophthalmic Drugs, Angiotensin-I Converting Enzyme (ACE) Inhibitors
  • 【研发状态】Launched-1984
  • 【合成情况】 
  • 〖来源〗Drugs Fut
  • 〖合成路线〗
  • 〖标题〗Enalapril maleate
  • 〖合成方法〗By reductocondensation of ethyl 2-oxo-4-phenylbutyrate (I) with alanylproline (II) by means of sodium cyanoborohydride or H2 over Raney-Ni or Pd/C in water.
  • 〖作者〗Hopkins, S.J.; Serradell, M.N.; Blancafort, P.; Castaer, J.
  • 〖参考〗Hopkins, S.J.; Serradell, M.N.; Blancafort, P.; Castaer, J.; Enalapril maleate. Drugs Fut 1982, 7, 8, 556
  • 〖出处〗Drugs Fut1982,7,(8):556
  • 〖备注〗Synthesis of 132957: By reductocondensation of ethyl 2-oxo-4-phenylbutyrate (I) with alanylproline (II) by means of sodium cyanoborohydride or H2 over Raney-Ni or Pd/C in water (1). (Scheme 13295701a) Reference 1. Patchett, A.A. et al.; A new class of angiotensin-converting anzyme inhibitors; Nature (Lond) 1980, 288, 280-283.
  • 〖来源〗Nature
  • 〖合成路线〗
  • 〖标题〗A new class of angiotensin-converting anzyme inhibitors
  • 〖合成方法〗By reductocondensation of ethyl 2-oxo-4-phenylbutyrate (I) with alanylproline (II) by means of sodium cyanoborohydride or H2 over Raney-Ni or Pd/C in water.
  • 〖作者〗Patchett, A.A.; et al.
  • 〖参考〗Patchett, A.A.; et al.; A new class of angiotensin-converting anzyme inhibitors. Nature 1980, 288, 280-283
  • 〖出处〗Nature1980,288,():280-283
  • 〖备注〗
 
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