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75-12-7

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摘 要:75-12-7, RTECS NUMBER : LQ0525000 CHEMICAL NAME : Formamide CAS REGISTRY NUMBER : 75-12-7 LAST UPDAT
    ◇◇◇化学鉴别信息◇◇◇
  • 【RTECS 编号】 LQ0525000
  • 【化学名】 Formamide
  • 【CAS 登记号】 75-12-7
  • 【上次更新时间】 199712
  • 【引用数据项】 42
  • 【分子式】 C-H3-N-O
  • 【分子量】 45.05
  • 【维斯韦塞(氏)线的符号】 ZVH
  • 【化合物描述】 Tumorigen Mutagen Reproductive Effector Primary Irritant
  • 【别名】 * Amid kyseliny mravenci * Carbamaldehyde * Formamide * Formimidic acid * Methanamide * Methanoic acid, amide
  • ◇◇◇卫生公害数据◇◇◇
    〖皮肤/眼睛刺激数据〗
  • 【测试类型】 Standard Draize test
  • 【接触途径】 Administration into the eye
  • 【测试物种】 Rodent - rabbit
  • 【剂量/时间】 100 mgREACTION SEVERITY : Severe
  • 【参考】 AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946
    〖急性毒性数据〗
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 5577 mg/kg
  • 【毒性作用】 Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - ataxia Kidney, Ureter, Bladder - incontinence
  • 【参考】 TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 9,163,1967
  • 【测试类型】 LD - Lethal dose
  • 【接触途径】 Administration onto the skin
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 >13500 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 32,223,1980
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Intraperitoneal
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 5700 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 26,596,1973
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Subcutaneous
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 >4 gm/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 APEPA2 Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle Pathologie. (Berlin, Ger.) V.254-263, 1966-69. For publisher information, see NSAPCC. Volume(issue)/page/year: 257,296,1967
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Unreported
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 3 gm/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 29,225,1973
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 3150 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 11,86,1969
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Intraperitoneal
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 2450 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 230,559,1957
  • 【测试类型】 LDLo - Lowest published lethal dose
  • 【接触途径】 Intravenous
  • 【测试物种】 Mammal - dog
  • 【剂量/时间】 1500 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
  • 【测试类型】 LDLo - Lowest published lethal dose
  • 【接触途径】 Administration onto the skin
  • 【测试物种】 Rodent - rabbit
  • 【剂量/时间】 6 gm/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 32,223,1980
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Intraperitoneal
  • 【测试物种】 Rodent - guinea pig
  • 【剂量/时间】 1250 mg/kg
  • 【毒性作用】 Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
  • 【参考】 TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 9,163,1967
  • 【测试类型】 LDLo - Lowest published lethal dose
  • 【接触途径】 Subcutaneous
  • 【测试物种】 Amphibian - frog
  • 【剂量/时间】 30 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Oral
  • 【测试物种】 Mammal - species unspecified
  • 【剂量/时间】 3150 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 39(4),86,1974
  • 〖其他多剂量毒性数据〗
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 910 mg/kg/26W-I
  • 【毒性作用】 Brain and Coverings - recordings from specific areas of CNS Liver - liver function tests impaired Kidney, Ureter, Bladder - proteinuria
  • 【参考】 GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(3),72,1987
  • 【测试类型】 TCLo - Lowest published toxic concentration
  • 【接触途径】 Inhalation
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 1500 ppm/6H/2W-I
  • 【毒性作用】 Blood - changes in leukocyte (WBC) count Blood - changes in platelet count Nutritional and Gross Metabolic - weight loss or decreased weight gain
  • 【参考】 FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,702,1989
  • 〖繁殖数据〗
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - ratDOSE : 2 gm/kgSEX/DURATION : female 7 day(s) after conception
  • 【毒性作用】 Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
  • 【参考】 85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H., Paris, Masson et Cie, 1971 Volume(issue)/page/year: -,95,1971
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - ratDOSE : 7980 mg/kgSEX/DURATION : female 7-12 day(s) after conception
  • 【毒性作用】 Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
  • 【参考】 85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H., Paris, Masson et Cie, 1971 Volume(issue)/page/year: -,95,1971
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Administration onto the skin
  • 【测试物种】 Rodent - ratDOSE : 1200 mg/kgSEX/DURATION : female 10-11 day(s) after conception
  • 【毒性作用】 Reproductive - Effects on Embryo or Fetus - fetal death
  • 【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 41,35,1977
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rabbitDOSE : 910 mg/kgSEX/DURATION : female 6-18 day(s) after conception
  • 【毒性作用】 Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
  • 【参考】 ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,1557,1980
    〖致突变数据〗
  • 【测试类型】 Mutation test systems - not otherwise specifiedTEST SYSTEM : Non-mammalian species Cells - not otherwise specified
  • 【剂量/时间】 500 mmol/L
  • 【参考】 CAANAT Comptes Rendus de l'Association des Anatomistes. (Nancy, France) V.1-56, 1899-1972. For publisher information, see ANOBAU. Volume(issue)/page/year: 56,712,1972
  • 【测试类型】 Cytogenetic analysisTEST SYSTEM : Non-mammalian species Cells - not otherwise specified
  • 【剂量/时间】 500 mmol/L
  • 【参考】 CAANAT Comptes Rendus de l'Association des Anatomistes. (Nancy, France) V.1-56, 1899-1972. For publisher information, see ANOBAU. Volume(issue)/page/year: 56,712,1972
  • ◇◇◇综述◇◇◇
  • ACGIH TLV-TWA 18 mg/m3 (10 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997
  • ◇◇◇职业接触限量◇◇◇
  • OEL-AUSTRALIA:TWA 10 ppm (15 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 10 ppm (18 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 20 ppm (30 mg/m3) JAN 1993 OEL-FINLAND:TWA 20 ppm (37 mg/m3);STEL 30 ppm (55 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 20 ppm (30 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 20 ppm (30 mg/m3) JAN 1993 OEL-RUSSIA:STEL 3 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 20 ppm (37 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 20 ppm (30 mg/m3);STEL 30 ppm (45 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
  • ◇◇◇NIOSH 标准发展和监测数据◇◇◇
    NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO FORMAMIDE-air:10H TWA 10 ppm (Sk)
  • 【参考】 NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992
  • 【NIOSH 职业性接触鉴定数据】 NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84454 No. of Facilities: 227 (estimated) No. of Industries: 6 No. of Occupations: 14 No. of Employees: 3195 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84454 No. of Facilities: 42 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 2724 (estimated) No. of Female Employees: 556 (estimated)
  • ◇◇◇在美国的情况◇◇◇
  • EPA GENETOX PROGRAM 1988, Negative: Cell transform.-RLV F344 rat embryo EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 47,26992,82 EPA TSCA Section 8(d) unpublished health/safety studies EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 NTP Carcinogenesis studies; on test (prechronic studies), October 1997
  • ◇◇◇全部数据完毕◇◇◇
 
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