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多烯紫杉醇 原料厂家】18973037251

  • 厂家:厂家电话王18872220689
  • 技术原料:厂家电话王18872220689
  • 含量:厂家电话王18872220689
  • 发布日期:2017-12-09 14:00
  • 有效期至:长期有效
  • 产品区域:湖南岳阳市
  • 浏览次数11
  • 申请代理
 
【多烯紫杉醇 原料厂家】18973037251】详细说明
厂家电话18973037251
多烯紫杉醇114977-28-5

中文名称: 多西他赛
中文同义词: 多烯他赛; ;紫杉特尔;多希紫杉醇;多烯紫杉醇
英文名称: Docetaxel
 
【多烯紫杉醇】CAS号: 114977-28-5
【多烯紫杉醇】分子式: C43H53NO14
【多烯紫杉醇】分子量: 807.88

【多烯紫杉醇】价格:194400元/公斤

【多烯紫杉醇】医药级 
【多烯紫杉醇】含量99% 
【多烯紫杉醇】结晶 
【多烯紫杉醇】白色 
【多烯紫杉醇】1kg/铝箔袋 


【多烯紫杉醇】用途 抗癌药。用于子宫癌。
【多烯紫杉醇】用途 抗肿瘤植物药,用于转移性乳腺癌和非小细胞肺癌的治疗


Docetaxel Basic information

Product Name: Docetaxel
Synonyms:N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl taxol; Taxotere

CAS:114977-28-5
Purity:99%
MF:C43H53NO14
MW:807.88
Melting point: 186-192 °C (dec.)
Properties: white Cryst

Usage: antineoplastic;binds to microtubules
Docetaxel belongs to taxanes-class drugs. It can boost the assembly of tubulin dimer into microtubules while stabilizing the microtubules by preventing the process of de-polymerization. Owing to the above two effects, it block the cells in the G2 and M phase, and thereby inhibiting cancer cell mitosis and proliferation. The pharmacological effect of docetaxel is higher than paclitaxel with former one having an intracellular concentration 3-fold of the later one. It also has a long retention time inside the cell and has a microtubule affinity twice of that of paclitaxel. As a microtubule-stabilizing agents and assembly accelerator, it has a 2 times larger activity than paclitaxel. As a microtubule depolymerization inhibitor, its activity is also 2 times larger than that of paclitaxel. In the in vitro tests of anti-tumor activity, it has been confirmed that the anti-tumor activity docetaxel is 1.3 to 12 times as high as paclitaxel. Clinical studies show that docetaxel has a much better efficacy than paclitaxel in treating the anthracycline-resistant breast cancer. 

Semi-synthesis of it uses the 10-deacetylbaccatin III as raw materials extracted from the needle-like leaves of the European yew Taxus baccata L. 10-deacetylbaccatin III can be converted to the compound product (I) after acylation. 

Cinnamic acid (330mg, 2.24mmo1), dicyclohexyl carbodiimide (DCC, 460mg, 2.24mmo1), the compound (I) (500mg, 0.56mmo1) and 4-dimethylaminopyridine (68mg, 0.56mmo1) are stirred under argon at 70 °C for 15h. Cooled, filtered, and the filter pellet should be further washed with toluene. Combine the filtrate and washings and concentrate under reduced pressure. Add methylene chloride to the residue; wash with 2% aqueous hydrochloric acid; dry it using anhydrous magnesium sulfate. The solvent is further evaporated under reduced pressure, and the remaining 1g residue is purified by column chromatography with the elution of hexane - ethyl acetate (7: 3) to obtain 540mg compound (II), yield 94%.
 
 
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