【药物名称】
Suplatast tosilate, IPD-1151T, IPD, MPD
【化学名】
(?-2-[N-[4-(3-Ethoxy-2-hydroxypropoxy)phenyl]carbamoyl]ethyldimethylsulfonium p-toluenesulfonate
【CAS登记号】
94055-76-2
【结构式】
【分子式】
C16-H26-N-O4-S.C7-H7-O3-S
【分子量】
499.65
【原研厂家】
Taiho (Originator), Yamanouchi (Licensee)
【作用类别】
Antiallergy/Antiasthmatic Drugs, Asthma Therapy, Atopic Dermatitis, Agents for, DERMATOLOGIC DRUGS, Drugs for Allergic Rhinitis, RENAL-UROLOGIC DRUGS, RESPIRATORY DRUGS, Treatment of Upper Respiratory Tract Disorders, Urologic Drugs, Mediator Release Inhibitors
【研发状态】
Launched-1995
【合成情况】
〖来源〗
Drugs Fut
〖合成路线〗
〖标题〗
IPD-1151T
〖合成方法〗
The condensation of 3-(methylmercapto)propionyl chloride (I) with 4-(3-ethoxy-2 hydroxypropoxy) aniline (II) by means of triethylamine in DMF gives the corresponding amide (III), which is then treated with methyl p-toluenesulfonate (IV) in dichloromethane.
〖作者〗
Prous, J.; Casta馿r, J.
〖参考〗
Prous, J.; Casta馿r, J.; IPD-1151T. Drugs Fut 1988, 13, 11, 952
〖出处〗
Drugs Fut1988,13,(11):952
〖备注〗
The condensation of 3-(methylmercapto)propionyl chloride (I) with 4-(3-ethoxy-2 hydroxypropoxy) aniline (II) by means of triethylamine in DMF gives the corresponding amide (III), which is then treated with methyl p-toluenesulfonate (IV) In dichloromethane.
〖来源〗
CH 659066; DE 3408708; FR 2542312; GB 2137986; JP 1984167564; JP 1984170062; JP 1985152459; US 4556737
〖合成路线〗
〖标题〗
Sulfonium cpds., processes for preparing the cpds. and pharmacological compsns. containing the same
〖合成方法〗
The condensation of 3-(methylmercapto)propionyl chloride (I) with 4-(3-ethoxy-2 hydroxypropoxy) aniline (II) by means of triethylamine in DMF gives the corresponding amide (III), which is then treated with methyl p-toluenesulfonate (IV) in dichloromethane.
〖作者〗
Hori, M.; Matsuura, N.; Ueda, S.; Yamawaki, I.; Yasumoto, M.; Tada, Y.; Koda, A. (Taiho Pharmaceutical Co., Ltd.)
〖参考〗
Hori, M.; Matsuura, N.; Ueda, S.; Yamawaki, I.; Yasumoto, M.; Tada, Y.; Koda, A. (Taiho Pharmaceutical Co., Ltd.); Sulfonium cpds., processes for preparing the cpds. and pharmacological compsns. containing the same. CH 659066; DE 3408708; FR 2542312; GB 2ases/10_23_olffwpmfmllgyiagl">\鞯વn耀VSShell\Common7\IDE\;C:\Pr
〖出处〗
CH 659066; DE 3408708; FR 2542312; GB 2137986; JP 1984167564; JP 1984170062; JP 1985152459; US 4556737,,():
〖备注〗
