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  • Terbogrel, BIBV-308-SE, BIBV-308,149979-74-8,C23-H27-N5-O2,6--药物合成数据库
  • 发布时间:2004-10-25 来源:本站整理
  • 【药物名称】
    Terbogrel, BIBV-308-SE, BIBV-308
    【化学名】
    6-[3-(3-tert-Butyl-2-cyanoguanidino)phenyl]-6-(3-pyridyl)-5(E)-hexenoic acid
    【CAS登记号】
    149979-74-8
    【结构式】
    Terbogrel, BIBV-308-SE, BIBV-308,149979-74-8,C23-H27-N5-O2,6--药物合成数据库
    【分子式】
    C23-H27-N5-O2
    【分子量】
    405.4993
    【原研厂家】
    Boehringer Ingelheim (Originator)
    【作用类别】
    Antiplatelet Therapy, CARDIOVASCULAR DRUGS, Coagulation Disorders Therapy, HEMATOLOGIC DRUGS, Peripheral Vascular Disease, Treatment of, Treatment of Peripheral Obstructive Vascular Disease, Prostanoid TP (Thromboxane A2) Antagonists, Thromboxane Synthase Inhibitors
    【研发状态】
    Phase II
    【合成情况】
     
    〖来源〗
    J Med Chem
    〖合成路线〗
    〖标题〗
    Guanidine derivatives as combined thromboxane A2 receptor antagonists and synthase inhibitors
    〖合成方法〗
    The reaction of (E)-6-(3-aminophenyl)-6-(3-pyridyl)-5-hexenoic acid methyl ester (I) with diphenyl N-cyanocarbinimidate (II) in isopropanol gives the N-cyanoisourea (III), which is condensed with tert-butylamine (IV) in refluxing isopropanol yielding the guanidine derivative (IV). Finally, hydrolysis of the ester group of (IV) with NaOH affords the target compound.
    〖作者〗
    Soyka, R.; et al.
    〖参考〗
    Soyka, R.; et al.; Guanidine derivatives as combined thromboxane A2 receptor antagonists and synthase inhibitors. J Med Chem 1999, 42, 7, 1235
    〖出处〗
    J Med Chem1999,42,(7):1235
    〖备注〗
    The reaction of (E)-6-(3-aminophenyl)-6-(3-pyridyl)-5-hexenoic acid methyl ester (I) with diphenyl N-cyanocarbinimidate (II) in isopropanol gives the N-cyanoisourea (III), which is condensed with tert-butylamine (IV) in refluxing isopropanol yielding the guanidine derivative (IV). Finally hydrolysis of the ester group of (IV) with NaOH affords the target compound.
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