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  • Norfloxacin, MK-0366, AM-715, Norflo, Lexinor, Baccidal, Seb--药物合成数据库
  • 发布时间：2004-10-25 来源：本站整理
  • 【药物名称】
    Norfloxacin, MK-0366, AM-715, Norflo, Lexinor, Baccidal, Sebercim, Noroxin, Fulgram, Barazan
    【化学名】
    1-Ethyl-6-fluoro-7-(1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
    【CAS登记号】
    70458-96-7, 68077-27-0 (monoHCl)
    【结构式】
    【分子式】
    C16-H18-F-N3-O3
    【分子量】
    319.339
    【原研厂家】
    ISF (Originator), Istituto Biologico Chemioterapico ABC (Originator), Merck & Co. (Originator), Merck Sharp & Dohme (Originator), Kyorin (Not Determined), AstraZeneca (Licensee), Roberts (Licensee)
    【作用类别】
    Antibacterial Drugs, Antibacterial Ophthalmic Drugs, ANTIINFECTIVE THERAPY, Ocular Antiinflammatory and Antiinfective Agents, OCULAR MEDICATIONS, Ophthalmic Drugs, DNA Gyrase Inhibitors, DNA Topoisomerase IV Inhibitors, Quinolones
    【研发状态】
    Launched-1984
    【合成情况】
    　
    〖来源〗
    Drugs Fut
    〖合成路线〗
    〖标题〗
    AM-715
    〖合成方法〗
    By condensation of 1-ethyl-6-fluoro-7-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (I) with piperazine (II) by heating at 170 C in water in a pressure tube.
    〖作者〗
    Blancafort, P.; Sweetman, A.J.; Casta馿r, J.; Serradell, M.N.
    〖参考〗
    Blancafort, P.; Sweetman, A.J.; Casta馿r, J.; Serradell, M.N.; AM-715. Drugs Fut 1981, 6, 8, 462
    〖出处〗
    Drugs Fut1981,6,(8):462
    〖备注〗
    Synthesis By condensation of 1-ethyl-6-fluoro-7-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (I) with piperazine (II) by heating at 170?in water in a pressure tube (1). Description Crystals, m.p 215-20? pentahydrate, m.p 226-7? HCl salt, m.p over 300?(1). Manufacturer Kyorin Pharmaceutical Co., Ltd., Tokyo (Japan) Reference 1. Kyorin Pharm. Co., Ltd.; US 4146719
    〖来源〗
    US 4146719
    〖合成路线〗
    〖标题〗
    Piperazinyl derivs. of quinoline carboxylic acids
    〖合成方法〗
    By condensation of 1-ethyl-6-fluoro-7-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (I) with piperazine (II) by heating at 170 C in water in a pressure tube.
    〖作者〗
    Irikura, T. (Kyorin Pharmaceutical Co., Ltd.)
    〖参考〗
    Irikura, T. (Kyorin Pharmaceutical Co., Ltd.); Piperazinyl derivs. of quinoline carboxylic acids. US 4146719
    〖出处〗
    US 4146719,,():
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