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  • Zaltoprofen, ZC-102, CN-100, Peon, Soleton,89482-00-8, 74711--药物合成数据库
  • 发布时间:2004-10-25 来源:本站整理
  • 【药物名称】
    Zaltoprofen, ZC-102, CN-100, Peon, Soleton
    【化学名】
    (?-2-(10-Oxo-10,11-dihydrodibenzo[b,f]thiepin-2-yl)propionic acid; (?-alpha-Methyl-10-oxo-10,11-dihydrodibenzo[b,f]thiepin-2-acetic acid
    【CAS登记号】
    89482-00-8, 74711-43-6 (undefined stereoch.)
    【结构式】
    Zaltoprofen, ZC-102, CN-100, Peon, Soleton,89482-00-8, 74711--药物合成数据库
    【分子式】
    C17-H14-O3-S
    【分子量】
    298.3606
    【原研厂家】
    Nippon Chemiphar (Originator), Zeria (Licensee)
    【作用类别】
    ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Antiarthritic Drugs, Non-Opioid Analgesics, RESPIRATORY DRUGS, Rheumatoid Arthritis, Treatment of, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Treatment of Upper Respiratory Tract Disorders, Cyclooxygenase Inhibitors, Non-Steroidal Antiinflammatory Drugs
    【研发状态】
    Launched-1993
    【合成情况】
     
    〖来源〗
    Drugs Fut
    〖合成路线〗
    〖标题〗
    CN-100
    〖合成方法〗
    The cyclization of 5-(1-cyanoethyl)-2-(phenylthio)phenylacetic acid (I) with polyphosphoric acid at 120 C gives 2-(10-oxo-10,11-dihydrodibenzo[b,flthiepin-2-yl)propionitrile (II), which is then hydrolyzed with KOH in refluxing ethanol-water.
    〖作者〗
    Prous, J.; Casta馿r, J.
    〖参考〗
    Prous, J.; Casta馿r, J.; CN-100. Drugs Fut 1988, 13, 4, 302
    〖出处〗
    Drugs Fut1988,13,(4):302
    〖备注〗
    The cyclization of 5-(1-cyanoethyl)-2-(phenylthio)phenylacetic acid (I) with polyphosphoric acid at 120 C gives 2-(10-oxo-10,11-dihydrodibenzo[b,flthiepin-2-yl)propionitrile (II ), which is then hydrolyzed with KOH in refluxing ethanol-water.
    〖来源〗
    DE 2941869; US 4247706
    〖合成路线〗
    〖标题〗
    Dibenzothiepine derivs., process for their prepara
    〖合成方法〗
    The cyclization of 5-(1-cyanoethyl)-2-(phenylthio)phenylacetic acid (I) with polyphosphoric acid at 120 C gives 2-(10-oxo-10,11-dihydrodibenzo[b,flthiepin-2-yl)propionitrile (II), which is then hydrolyzed with KOH in refluxing ethanol-water.
    〖作者〗
    Fujimoto, Y.; Yamabe, S. (Nippon Chemiphar Co., Ltd.)
    〖参考〗
    Fujimoto, Y.; Yamabe, S. (Nippon Chemiphar Co., Ltd.); Dibenzothiepine derivs., process for their prepara. DE 2941869; US 4247706
    〖出处〗
    DE 2941869; US 4247706,,():
    〖备注〗
    The cyclization of 5-(1-cyanoethyl)-2-(phenylthio)phenylacetic acid (I) with polyphosphoric acid at 120 C gives 2-(10-oxo-10,11-dihydrodibenzo[b,flthiepin-2-yl)propionitrile (II ), which is then hydrolyzed with KOH in refluxing ethanol-water.
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