◇◇◇化学鉴别信息◇◇◇
【RTECS 编号】
TX4410000
【化学名】
Propane, 2-chloro-
【CAS 登记号】
75-29-6
【BEILSTEIN 参考号】
1730782
【参考】
4-01-00-00191 (Beilstein Handbook Reference)
【上次更新时间】
199710
【引用数据项】
12
【分子式】
C3-H7-Cl
【分子量】
78.55
【化合物描述】
Mutagen
【别名】
* Chlorodimethylmethane * Isoprid * Isopropylchloride * Narcosop * sec-Propyl chloride * 2-Propyl chloride
◇◇◇卫生公害数据◇◇◇
〖急性毒性数据〗
【测试类型】
LD50 - Lethal dose, 50 percent kill
【接触途径】
Oral
【测试物种】
Rodent - rat
【剂量/时间】
5 gm/kg
【毒性作用】
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis
【参考】
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 55(7),93,1990
【测试类型】
LC50 - Lethal concentration, 50 percent kill
【接触途径】
Inhalation
【测试物种】
Rodent - rat
【剂量/时间】
120 gm/m3
【毒性作用】
Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
【参考】
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 55(7),93,1990
【测试类型】
LD50 - Lethal dose, 50 percent kill
【接触途径】
Oral
【测试物种】
Rodent - mouse
【剂量/时间】
1300 mg/kg
【毒性作用】
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis
【参考】
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 55(7),93,1990
【测试类型】
LC50 - Lethal concentration, 50 percent kill
【接触途径】
Inhalation
【测试物种】
Rodent - mouse
【剂量/时间】
119 gm/m3
【毒性作用】
Details of toxic effects not reported other than lethal dose value
【参考】
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 55(7),93,1990
〖其他多剂量毒性数据〗
【测试类型】
TCLo - Lowest published toxic concentration
【接触途径】
Inhalation
【测试物种】
Rodent - rat
【剂量/时间】
236 gm/m3/30M/1W-I
【毒性作用】
Liver - other changes
【参考】
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 80,139,1944
〖致突变数据〗
【测试类型】
Mutation in microorganismsTEST SYSTEM : Bacteria - Salmonella typhimurium
【剂量/时间】
1 gm/plate
【参考】
DTESD7 52 Vanderbilt Ave., New York, NY 10017) V.1-15, 1977-87. Discontinued 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977- Volume(issue)/page/year: 2,249,1977
◇◇◇NIOSH 标准发展和监测数据◇◇◇
【NIOSH 职业性接触鉴定数据】
NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5379 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 145 (estimated) No. of Female Employees: 3 (estimated)
◇◇◇在美国的情况◇◇◇
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA Section 8(d) unpublished health/safety studies EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
◇◇◇全部数据完毕◇◇◇
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