DM8575000

Benzoyl peroxide

94-36-0

199712

45

C14-H10-O4

242.24

RVOOVR

Tumorigen Mutagen Primary Irritant

* Acnegel * Aztec BPO * Benzoperoxide * Benzoylperoxid * Benzoyl peroxide * Benzoylperoxyde * Benzoyl superoxide * BZF-60 * Cadat BPO * Cadox B-CH 50 * Cadox BS * Debroxide * Dibenzoylperoxid * Dibenzoyl peroxide * Dibenzoylperoxyde * Diphenylglyoxal peroxide * Fostex * Garox * Incidol * Loroxide * Lucidol * Luperco AA * Luperco AST * Luperox FL * Nayper B and BO * Norox bzp-250 * Norox bzp-C-35 * Novadelox * Oxylite * Panoxyl * Perossido di benzoile * Peroxide, dibenzoyl * Peroxyde de benzoyle * Persadox * Quinolor compound * Superox 744 * Theraderm * Topex * Vanoxide * Xerac

Standard Draize test

Administration into the eye

Rodent - rabbit

500 mg/24HREACTION SEVERITY : Mild

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,324,1986

LD50 - Lethal dose, 50 percent kill

Oral

Rodent - rat

7710 mg/kg

Lungs, Thorax, or Respiration - cyanosis Liver - other changes Kidney, Ureter, Bladder - other changes in urine composition

ARCOC* ARCO Chemical Company Report. (3801 West Chester Pike, Newton Square, PA 19073) Volume(issue)/page/year: JUN1982

LD50 - Lethal dose, 50 percent kill

Oral

Rodent - mouse

5700 mg/kg

Details of toxic effects not reported other than lethal dose value

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 32(3),31,1967

LD50 - Lethal dose, 50 percent kill

Intraperitoneal

Rodent - mouse

250 mg/kg

Details of toxic effects not reported other than lethal dose value

IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK) Volume(issue)/page/year: 3,93,1976

LD50 - Lethal dose, 50 percent kill

Administration onto the skin

Mammal - species unspecified

>1 gm/kg

Details of toxic effects not reported other than lethal dose value

KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: #900713

TDLo - Lowest published toxic dose

Administration onto the skin

Rodent - mouse

24 gm/kg/30W-I

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 213,1023,1981

DNA repairTEST SYSTEM : Bacteria - Escherichia coli

250 ug/well

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 133,161,1984

DNA damageTEST SYSTEM : Human Cells - not otherwise specified

100 umol/L

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,2522,1985

DNA inhibitionTEST SYSTEM : Human Cells - not otherwise specified

56 umol/L

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,2522,1985

Mutation test systems - not otherwise specifiedTEST SYSTEM : Human Cells - not otherwise specified

56 umol/L

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,2522,1985

Mutation in mammalian somatic cellsTEST SYSTEM : Human Kidney

300 umol/L

CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 13,1783,1992

Unscheduled DNA synthesisTEST SYSTEM : Rodent - rat Liver

100 pmol/L

CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,1547,1984

DNA damageTEST SYSTEM : Rodent - mouse Cells - not otherwise specified

1 umol/L

PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 24,108,1983 ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 5 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 36,267,1985 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 36,267,1985 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963- Volume(issue)/page/year: 10(3),49,1973 MSHA STANDARD-air:TWA 5 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,23,1971 OSHA PEL (Gen Indu):8H TWA 5 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 OEL-AUSTRALIA:TWA 5 mg/m3 JAN 1993 OEL-AUSTRIA:TWA 5 mg/m3 JAN 1993 OEL-BELGIUM:TWA 5 mg/m3 JAN 1993 OEL-DENMARK:TWA 5 mg/m3 JAN 1993 OEL-FINLAND:TWA 5 mg/m3;STEL 10 mg/m3;Skin JAN 1993 OEL-FRANCE:TWA 5 mg/m3 JAN 1993 OEL-GERMANY:TWA 5 mg/m3 JAN 1993 OEL-HUNGARY:TWA 5 mg/m3;STEL 10 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 mg/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 5 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 5 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 5 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO BENZOYL PEROXIDE-air:10H TWA 5 mg/m3

NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992

NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 11280 No. of Facilities: 5255 (estimated) No. of Industries: 47 No. of Occupations: 42 No. of Employees: 32909 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 11280 No. of Facilities: 7331 (estimated) No. of Industries: 62 No. of Occupations: 75 No. of Employees: 87420 (estimated) No. of Female Employees: 11192 (estimated) EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9 EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 NIOSH Analytical Method, 1994: Benzoyl peroxide, 5009