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,C15H10N2O,234.2598,5-cyano-5,11-dihydro-10H-dibenzo[b,f]aze

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摘 要:,C15H10N2O,234.2598,5-cyano-5,11-dihydro-10H-dibenzo[b,f]azepin-10-one
  • 【化学名】5-cyano-5,11-dihydro-10H-dibenzo[b,f]azepin-10-one
  • 【CAS登记号】
  • 【结构式】,C15H10N2O,234.2598,5-cyano-5,11-dihydro-10H-dibenzo[b,f]aze--药物合成数据库
  • 【分子式】C15H10N2O
  • 【分子量】234.2598
  • 【来源】
  • 【合成情况】 
  • 〖目标产物〗
  • 〖合成路线〗
  • 〖合成方法〗The dibenzoazepine-5-carbonitrile (I) is converted to its 11-cyano isomer (II) in the presence of potassium tert-butoxide in dichloroethane. Alkylation of the keto nitrile (II) with ethyl bromoacetate leads to the dibenzoazepine derivative (III). Rearrangement of (III) under basic conditions affords the indoloquinazoline (IV). Finally, alkaline hydrolysis of methyl ester (IV) provides the corresponding carboxylic acid.
  • 〖参考〗Vangrevelinghe, E.; Zimmermann, K.; Schoepfer, J.; Portmann, R.; Fabbro, D.; Furet, P.; Discovery of a potent and selective protein kinase CK2 inhibitor by high-throughput docking. J Med Chem 2003, 46, 13, 2656
 
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