当前位置: 首页 » 资料 » 药物合成路线 » Luliconazole, PR-2699, NND-502,187164-19-8,C14-H9-Cl2-N3-S2,

Luliconazole, PR-2699, NND-502,187164-19-8,C14-H9-Cl2-N3-S2,

放大字体  缩小字体 更新日期:2016-02-10  浏览次数:91
摘 要:Luliconazole, PR-2699, NND-502,187164-19-8,C14-H9-Cl2-N3-S2,(-)-(R)-(E)-2-[4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-(1-imidazolyl)acetonitrile
  • 【药物名称】Luliconazole, PR-2699, NND-502
  • 【化学名】(-)-(R)-(E)-2-[4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-(1-imidazolyl)acetonitrile
  • 【CAS登记号】187164-19-8
  • 【结构式】Luliconazole, PR-2699, NND-502,187164-19-8,C14-H9-Cl2-N3-S2,--药物合成数据库
  • 【分子式】C14-H9-Cl2-N3-S2
  • 【分子量】354.2841
  • 【原研厂家】Nihon Nohyaku (Originator), Bayer (Licensee)
  • 【作用类别】Antifungal Agents, ANTIINFECTIVE THERAPY
  • 【研发状态】Phase I
  • 【合成情况】 
  • 〖来源〗JP 1997100279; JP 1998158168; US 5900488; WO 9702821
  • 〖合成路线〗
  • 〖标题〗Antifungal agent, cpd. therefor, process for producing the same
  • 〖合成方法〗This compound has been obtained by two similar ways: The enantiocontrolled reduction of 2,4-dichlorophenacyl bromide (I) with BH3/THF and a chiral oxazaborole catalyst gives 1(S)-(2,4-dichlorophenyl)-2-bromoethanol (II), which is treated with Ms-Cl and TEA in dichloromethane to yield the corresponding mesylate (III). Finally, this compound is cyclized with 2-(1-imidazolyl)-3,3-disulfanylacrylonitrile (VI) by means of KOH in DMSO. Alternatively, 1(S)-(2,4-dichlorophenyl)ethane-1,2-diol (VII) is treated with Ms-Cl and TEA in dichloromethane to give the corresponding dimesylate (VIII), which is condensed with the acrylonitrile (VI) with KOH as before. The intermediate acrylonitrile (VI) has been obtained by condensation of 2-(1-imidazolyl)acetonitrile (IV) with CS2 (V) by means of KOH in DMSO.
  • 〖作者〗Kodama, H.; Niwano, Y.; Kanai, K.; Yoshida, M. (Nihon Nohyaku Co., Ltd.)
  • 〖参考〗Kodama, H.; Niwano, Y.; Kanai, K.; Yoshida, M. (Nihon Nohyaku Co., Ltd.); Antifungal agent, cpd. therefor, process for producing the same. JP 1997100279; JP 1998158168; US 5900488; WO 9702821
  • 〖出处〗JP 1997100279; JP 1998158168; US 5900488; WO 9702821,,():
  • 〖备注〗
 
本文导航:
  • (1) Luliconazole, PR-2699, NND-502,187164-19-8,C14-H9-Cl2-N3-S2,
  • 下一篇:鳖甲
  • 上一篇:暂无
 
[ 资料搜索 ]  [ 加入收藏 ]  [ 告诉好友 ]  [ 打印本文 ]  [ 关闭窗口 ]

 

 
推荐图文
推荐资料
热门关注