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Terbogrel, BIBV-308-SE, BIBV-308,149979-74-8,C23-H27-N5-O2,6

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摘 要:Terbogrel, BIBV-308-SE, BIBV-308,149979-74-8,C23-H27-N5-O2,6-[3-(3-tert-Butyl-2-cyanoguanidino)phenyl]-6-(3-pyridyl)-5(E)-hexenoic acid
  • 【药物名称】Terbogrel, BIBV-308-SE, BIBV-308
  • 【化学名】6-[3-(3-tert-Butyl-2-cyanoguanidino)phenyl]-6-(3-pyridyl)-5(E)-hexenoic acid
  • 【CAS登记号】149979-74-8
  • 【结构式】Terbogrel, BIBV-308-SE, BIBV-308,149979-74-8,C23-H27-N5-O2,6--药物合成数据库
  • 【分子式】C23-H27-N5-O2
  • 【分子量】405.4993
  • 【原研厂家】Boehringer Ingelheim (Originator)
  • 【作用类别】Antiplatelet Therapy, CARDIOVASCULAR DRUGS, Coagulation Disorders Therapy, HEMATOLOGIC DRUGS, Peripheral Vascular Disease, Treatment of, Treatment of Peripheral Obstructive Vascular Disease, Prostanoid TP (Thromboxane A2) Antagonists, Thromboxane Synthase Inhibitors
  • 【研发状态】Phase II
  • 【合成情况】 
  • 〖来源〗J Med Chem
  • 〖合成路线〗
  • 〖标题〗Guanidine derivatives as combined thromboxane A2 receptor antagonists and synthase inhibitors
  • 〖合成方法〗The reaction of (E)-6-(3-aminophenyl)-6-(3-pyridyl)-5-hexenoic acid methyl ester (I) with diphenyl N-cyanocarbinimidate (II) in isopropanol gives the N-cyanoisourea (III), which is condensed with tert-butylamine (IV) in refluxing isopropanol yielding the guanidine derivative (IV). Finally, hydrolysis of the ester group of (IV) with NaOH affords the target compound.
  • 〖作者〗Soyka, R.; et al.
  • 〖参考〗Soyka, R.; et al.; Guanidine derivatives as combined thromboxane A2 receptor antagonists and synthase inhibitors. J Med Chem 1999, 42, 7, 1235
  • 〖出处〗J Med Chem1999,42,(7):1235
  • 〖备注〗The reaction of (E)-6-(3-aminophenyl)-6-(3-pyridyl)-5-hexenoic acid methyl ester (I) with diphenyl N-cyanocarbinimidate (II) in isopropanol gives the N-cyanoisourea (III), which is condensed with tert-butylamine (IV) in refluxing isopropanol yielding the guanidine derivative (IV). Finally hydrolysis of the ester group of (IV) with NaOH affords the target compound.
 
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