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Sertaconazole nitrate, FI-7045(free base), Ertaczo, Ginederm

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摘 要:Sertaconazole nitrate, FI-7045(free base), Ertaczo, Ginedermofix, Zalain, Dermoseptic, Extens, Dermofix, Fisderm,99592-39-9, 99592-32-2 (free base),C20-H15-Cl3-N2-O-S.H-N-O3,(R,S)-(?-1-[2-(7-Chlorobenzo[b]thien-3-ylmethoxy)-2-(2,4-dichlorophenyl)ethy
  • 【药物名称】Sertaconazole nitrate, FI-7045(free base), Ertaczo, Ginedermofix, Zalain, Dermoseptic, Extens, Dermofix, Fisderm
  • 【化学名】(R,S)-(?-1-[2-(7-Chlorobenzo[b]thien-3-ylmethoxy)-2-(2,4-dichlorophenyl)ethyl]imidazole nitrate
  • 【CAS登记号】99592-39-9, 99592-32-2 (free base)
  • 【结构式】Sertaconazole nitrate, FI-7045(free base), Ertaczo, Ginederm--药物合成数据库
  • 【分子式】C20-H15-Cl3-N2-O-S.H-N-O3
  • 【分子量】500.7884
  • 【原研厂家】Ferrer (Originator), Robert Labs. (Originator), Mylan (Licensee)
  • 【作用类别】Antifungal Agents, ANTIINFECTIVE THERAPY
  • 【研发状态】Launched-1992
  • 【合成情况】 
  • 〖来源〗Arzneim-Forsch Drug Res
  • 〖合成路线〗
  • 〖标题〗Synthesis and antimycotic activity of (benzo[b]thienyl)methyl ethers of 1 -(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol and of (Z)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone oxime
  • 〖合成方法〗Sertaconazole nitrate has been synthesized by condensation of 1-(2,4-dichlorophenyl)-2-(1-imidazolyl)ethanol (I) with 3-(bromomethyl)-7-chlorobenzo[b]thiophene (II) by means of NaH in HMPT, followed by salification with HNO3.
  • 〖作者〗Moreno-Maas, M.; Raga, M.M.; Palacn, C.; Ortiz, J.A.; Cuberes, M.R.; Castell? J.M.
  • 〖参考〗Moreno-Maas, M.; Raga, M.M.; Palacn, C.; Ortiz, J.A.; Cuberes, M.R.; Castell? J.M.; Synthesis and antimycotic activity of (benzo[b]thienyl)methyl ethers of 1 -(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol and of (Z)-1-(2,4-dichlorophenyl)-2-(1H-imidazo55273-05-7 (free base)/li> li>??p耀?ul class="old_db">li>s
  • 〖出处〗Arzneim-Forsch Drug Res1992,42,(5a):691
  • 〖备注〗Sertaconazole nitrate has been synthesized by condensation of 1-(2,4-dichlorophenyl)-2-(1-imidazolyl)ethanol (I) with 3-(bromomethyl)-7-chlorobenzo[b]thiophene (II) by means of NaH in HMPT, followed by salification with HNO3.
 
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