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Zaltoprofen, ZC-102, CN-100, Peon, Soleton,89482-00-8, 74711

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摘 要:Zaltoprofen, ZC-102, CN-100, Peon, Soleton,89482-00-8, 74711-43-6 (undefined stereoch.),C17-H14-O3-S,(?-2-(10-Oxo-10,11-dihydrodibenzo[b,f]thiepin-2-yl)propionic acid; (?-alpha-Methyl-10-oxo-10,11-dihydrodibenzo[b,f]thiepin-2-acetic acid
  • 【药物名称】Zaltoprofen, ZC-102, CN-100, Peon, Soleton
  • 【化学名】(?-2-(10-Oxo-10,11-dihydrodibenzo[b,f]thiepin-2-yl)propionic acid; (?-alpha-Methyl-10-oxo-10,11-dihydrodibenzo[b,f]thiepin-2-acetic acid
  • 【CAS登记号】89482-00-8, 74711-43-6 (undefined stereoch.)
  • 【结构式】Zaltoprofen, ZC-102, CN-100, Peon, Soleton,89482-00-8, 74711--药物合成数据库
  • 【分子式】C17-H14-O3-S
  • 【分子量】298.3606
  • 【原研厂家】Nippon Chemiphar (Originator), Zeria (Licensee)
  • 【作用类别】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Antiarthritic Drugs, Non-Opioid Analgesics, RESPIRATORY DRUGS, Rheumatoid Arthritis, Treatment of, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Treatment of Upper Respiratory Tract Disorders, Cyclooxygenase Inhibitors, Non-Steroidal Antiinflammatory Drugs
  • 【研发状态】Launched-1993
  • 【合成情况】 
  • 〖来源〗Drugs Fut
  • 〖合成路线〗
  • 〖标题〗CN-100
  • 〖合成方法〗The cyclization of 5-(1-cyanoethyl)-2-(phenylthio)phenylacetic acid (I) with polyphosphoric acid at 120 C gives 2-(10-oxo-10,11-dihydrodibenzo[b,flthiepin-2-yl)propionitrile (II), which is then hydrolyzed with KOH in refluxing ethanol-water.
  • 〖作者〗Prous, J.; Castaer, J.
  • 〖参考〗Prous, J.; Castaer, J.; CN-100. Drugs Fut 1988, 13, 4, 302
  • 〖出处〗Drugs Fut1988,13,(4):302
  • 〖备注〗The cyclization of 5-(1-cyanoethyl)-2-(phenylthio)phenylacetic acid (I) with polyphosphoric acid at 120 C gives 2-(10-oxo-10,11-dihydrodibenzo[b,flthiepin-2-yl)propionitrile (II ), which is then hydrolyzed with KOH in refluxing ethanol-water.
  • 〖来源〗DE 2941869; US 4247706
  • 〖合成路线〗
  • 〖标题〗Dibenzothiepine derivs., process for their prepara
  • 〖合成方法〗The cyclization of 5-(1-cyanoethyl)-2-(phenylthio)phenylacetic acid (I) with polyphosphoric acid at 120 C gives 2-(10-oxo-10,11-dihydrodibenzo[b,flthiepin-2-yl)propionitrile (II), which is then hydrolyzed with KOH in refluxing ethanol-water.
  • 〖作者〗Fujimoto, Y.; Yamabe, S. (Nippon Chemiphar Co., Ltd.)
  • 〖参考〗Fujimoto, Y.; Yamabe, S. (Nippon Chemiphar Co., Ltd.); Dibenzothiepine derivs., process for their prepara. DE 2941869; US 4247706
  • 〖出处〗DE 2941869; US 4247706,,():
  • 〖备注〗The cyclization of 5-(1-cyanoethyl)-2-(phenylthio)phenylacetic acid (I) with polyphosphoric acid at 120 C gives 2-(10-oxo-10,11-dihydrodibenzo[b,flthiepin-2-yl)propionitrile (II ), which is then hydrolyzed with KOH in refluxing ethanol-water.
 
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