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54749-90-5

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摘 要:54749-90-5, RTECS NUMBER : LZ5758000 CHEMICAL NAME : Glucopyranose, 2-deoxy-2-(3-(2-chloroethyl)-3-n
    ◇◇◇化学鉴别信息◇◇◇
  • 【RTECS 编号】 LZ5758000
  • 【化学名】 Glucopyranose, 2-deoxy-2-(3-(2-chloroethyl)-3-nitrosoureido)-, D-
  • 【CAS 登记号】 54749-90-5
  • 【上次更新时间】 199706
  • 【引用数据项】 40
  • 【分子式】 C9-H16-Cl-N3-O7
  • 【分子量】 313.73
  • 【维斯韦塞(氏)线的符号】 T6OTJ BQ CMVNNO&2G DQ EQ F1Q
  • 【化合物描述】 Tumorigen Drug Mutagen Human
  • 【别名】 * 1-(2-Chloroethyl)-3-(D-glucopyranos-2-yl)-1-nitrosourea * 2-((((2-Chloroethyl)nitrosoamino)carbonyl)amino)-2-deoxy-D-glucose * 2-(3-(2-Chloroethyl)-3-nitrosoureido)-2-deoxy-D-glucosopyranose * 2-(3-(2-Chloroethyl)-3-nitrosoureido)-D-gluco-pyranose * Chlorozotocin * CHLZ * DCNU * D-Glucopyranose, 2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)-2-deoxy- * D-Glucose, 2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)-2-deoxy- * NSC 178248 * Urea, 1-(2-chloroethyl)-3-(D-glucopyranos-2-yl)-1-nitroso-
  • ◇◇◇卫生公害数据◇◇◇
    〖急性毒性数据〗
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Intravenous
  • 【测试物种】 Human
  • 【剂量/时间】 2027 ug/kg/5D
  • 【毒性作用】 Blood - leukopenia Blood - thrombocytopenia Blood - changes in bone marrow (not otherwise specified)
  • 【参考】 CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 63,17,1979
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Intravenous
  • 【测试物种】 Human - man
  • 【剂量/时间】 500 mg/kg
  • 【毒性作用】 Behavioral - anorexia (human) Gastrointestinal - nausea or vomiting Blood - thrombocytopenia
  • 【参考】 CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 46,2365,1980
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Intraperitoneal
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 28 mg/kg
  • 【毒性作用】 Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - other changes
  • 【参考】 CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 8,133,1979
  • 【测试类型】 LDLo - Lowest published lethal dose
  • 【接触途径】 Subcutaneous
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 40 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 82,540,1986
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Intravenous
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 22500 ug/kg
  • 【毒性作用】 Lungs, Thorax, or Respiration - chronic pulmonary edema Gastrointestinal - ulceration or bleeding from stomach Blood - changes in bone marrow (not otherwise specified)
  • 【参考】 ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967- Volume(issue)/page/year: 37,177,1980
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Intraperitoneal
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 35 mg/kg
  • 【毒性作用】 Tumorigenic - active as anti-cancer agent
  • 【参考】 INSSDM INSERM Symposium. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) No.1- 1975- Volume(issue)/page/year: 19,123,1981
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Subcutaneous
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 66230 ug/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Intravenous
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 24900 ug/kg
  • 【毒性作用】 Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in spleen
  • 【参考】 TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 12,31,1979
  • 【测试类型】 LDLo - Lowest published lethal dose
  • 【接触途径】 Oral
  • 【测试物种】 Mammal - dog
  • 【剂量/时间】 3 mg/kg
  • 【毒性作用】 Gastrointestinal - changes in structure or function of esophagus Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
  • 【参考】 TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 12,31,1979
  • 【测试类型】 LDLo - Lowest published lethal dose
  • 【接触途径】 Oral
  • 【测试物种】 Primate - monkey
  • 【剂量/时间】 400 mg/kg
  • 【毒性作用】 Behavioral - food intake (animal) Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - weight loss or decreased weight gain
  • 【参考】 TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 12,31,1979
  • 〖其他多剂量毒性数据〗
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Intravenous
  • 【测试物种】 Mammal - dog
  • 【剂量/时间】 7500 ug/kg/5D-I
  • 【毒性作用】 Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death
  • 【参考】 TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 12,31,1979
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Intravenous
  • 【测试物种】 Primate - monkey
  • 【剂量/时间】 200 mg/kg/5D-I
  • 【毒性作用】 Gastrointestinal - changes in structure or function of endocrine pancreas Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Endocrine - hyperglycemia
  • 【参考】 TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 12,31,1979
  • 〖致肿瘤数据数据〗
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Intraperitoneal
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 34 mg/kg/85W-I
  • 【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors
  • 【参考】 CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 8,133,1979
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Intravenous
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 16 mg/kg/60W-I
  • 【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
  • 【参考】 DTESD7 52 Vanderbilt Ave., New York, NY 10017) V.1-15, 1977-87. Discontinued 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977- Volume(issue)/page/year: 8,273,1980
  • 【测试类型】 TD - Toxic dose (other than lowest)
  • 【接触途径】 Intravenous
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 64 mg/kg/60W-I
  • 【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors
  • 【参考】 DTESD7 52 Vanderbilt Ave., New York, NY 10017) V.1-15, 1977-87. Discontinued 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977- Volume(issue)/page/year: 8,273,1980
  • 【测试类型】 TD - Toxic dose (other than lowest)
  • 【接触途径】 Intraperitoneal
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 80 mg/kg/8W-I
  • 【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors
  • 【参考】 BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 57,469,1988
    〖致突变数据〗
  • 【测试类型】 Mutation in microorganismsTEST SYSTEM : Bacteria - Salmonella typhimurium
  • 【剂量/时间】 100 nmol/plate
  • 【参考】 JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 65,149,1980
  • 【测试类型】 Sex chromosome loss and nondisjunction
  • 【接触途径】 OralTEST SYSTEM : Insect - Drosophila melanogaster
  • 【剂量/时间】 1 mmol/L
  • 【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 57,297,1978
  • 【测试类型】 DNA damage
  • 【接触途径】 IntraperitonealTEST SYSTEM : Rodent - rat
  • 【剂量/时间】 100 umol/kg
  • 【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,514,1984
  • 【测试类型】 DNA damageTEST SYSTEM : Rodent - rat Mammary gland
  • 【剂量/时间】 100 umol/L
  • 【参考】 BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 35,1171,1986
  • 【测试类型】 Sister chromatid exchangeTEST SYSTEM : Rodent - rat Mammary gland
  • 【剂量/时间】 5 umol/L
  • 【参考】 BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 35,1171,1986
  • 【测试类型】 Sister chromatid exchangeTEST SYSTEM : Rodent - rat Cells - not otherwise specified
  • 【剂量/时间】 1 umol/L
  • 【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,473,1983
  • 【测试类型】 DNA damageTEST SYSTEM : Rodent - mouse Leukocyte
  • 【剂量/时间】 50 umol/L
  • 【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 38,3197,1978
  • 【测试类型】 DNA damageTEST SYSTEM : Rodent - mouse Bone marrow
  • 【剂量/时间】 100 umol/L
  • 【参考】 INSSDM INSERM Symposium. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) No.1- 1975- Volume(issue)/page/year: 19,49,1981
  • 【测试类型】 DNA inhibitionTEST SYSTEM : Rodent - mouse Cells - not otherwise specified
  • 【剂量/时间】 15 mg/kg
  • 【参考】 INSSDM INSERM Symposium. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) No.1- 1975- Volume(issue)/page/year: 19,85,1981
  • 【测试类型】 DNA inhibitionTEST SYSTEM : Rodent - mouse Leukocyte
  • 【剂量/时间】 20 mg/L
  • 【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 40,3723,1980
  • 【测试类型】 Mutation test systems - not otherwise specifiedTEST SYSTEM : Rodent - mouse Leukocyte
  • 【剂量/时间】 15 mg/kg
  • 【参考】 INSSDM INSERM Symposium. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) No.1- 1975- Volume(issue)/page/year: 19,85,1981
  • 【测试类型】 DNA damageTEST SYSTEM : Rodent - mouse Bone marrow
  • 【剂量/时间】 100 umol/L
  • 【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,2605,1982
  • 【测试类型】 Sister chromatid exchangeTEST SYSTEM : Rodent - mouse Leukocyte
  • 【剂量/时间】 350 nmol/L
  • 【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 207,179,1988
  • 【测试类型】 DNA damageTEST SYSTEM : Rodent - hamster Lung
  • 【剂量/时间】 12800 nmol/L
  • 【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 38,3379,1978
  • 【测试类型】 Mutation in mammalian somatic cellsTEST SYSTEM : Rodent - hamster Lung
  • 【剂量/时间】 10 umol/L
  • 【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 40,2719,1980
  • 【测试类型】 DNA damageTEST SYSTEM : Mammal - species unspecified Lymphocyte
  • 【剂量/时间】 10 mmol/L
  • 【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,1887,1984
  • ◇◇◇综述◇◇◇
  • IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,65,1990 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,65,1990 IARC Cancer Review:Group 2A IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,65,1990
  • ◇◇◇NIOSH 标准发展和监测数据◇◇◇
  • 【NIOSH 职业性接触鉴定数据】 NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5397 No. of Facilities: 45 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 267 (estimated) No. of Female Employees: 223 (estimated)
  • ◇◇◇在美国的情况◇◇◇
  • EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
  • ◇◇◇全部数据完毕◇◇◇
 
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