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818-61-1

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摘 要:818-61-1, RTECS NUMBER : AT1750000 CHEMICAL NAME : Acrylic acid, 2-hydroxyethyl ester CAS REGISTRY N
    ◇◇◇化学鉴别信息◇◇◇
  • 【RTECS 编号】 AT1750000
  • 【化学名】 Acrylic acid, 2-hydroxyethyl ester
  • 【CAS 登记号】 818-61-1
  • 【BEILSTEIN 参考号】 0969853
  • 【参考】 4-02-00-01469 (Beilstein Handbook Reference)
  • 【上次更新时间】 199801
  • 【引用数据项】 20
  • 【分子式】 C5-H8-O3
  • 【分子量】 116.13
  • 【维斯韦塞(氏)线的符号】 Q2OV1U1
  • 【化合物描述】 Mutagen Primary Irritant
  • 【别名】 * 2-(Acryloyloxy)ethanol * Bisomer 2HEA * Ethylene glycol, acrylate * Ethylene glycol, monoacrylate * Hydroxyethyl acrylate * beta-Hydroxyethyl acrylate * 2-Hydroxyethyl acrylate * 2-Hydroxyethylester kyseliny akrylove * 2-Propenoic acid, 2-hydroxyethyl ester
  • ◇◇◇卫生公害数据◇◇◇
    〖皮肤/眼睛刺激数据〗
  • 【测试类型】 Open irritation test
  • 【接触途径】 Administration onto the skin
  • 【测试物种】 Rodent - rabbit
  • 【剂量/时间】 500 mgREACTION SEVERITY : Moderate
  • 【参考】 UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 3/23/1973
  • 【测试类型】 Open irritation test
  • 【接触途径】 Administration onto the skin
  • 【测试物种】 Rodent - rabbit
  • 【剂量/时间】 10 mg/24HREACTION SEVERITY : Mild
  • 【参考】 AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951
  • 【测试类型】 Standard Draize test
  • 【接触途径】 Administration into the eye
  • 【测试物种】 Rodent - rabbit
  • 【剂量/时间】 1 mgREACTION SEVERITY : Severe
  • 【参考】 UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 3/23/1973
  • 【测试类型】 Standard Draize test
  • 【接触途径】 Administration into the eye
  • 【测试物种】 Rodent - rabbit
  • 【剂量/时间】 20 mg/24HREACTION SEVERITY : Moderate
  • 【参考】 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,666,1986
    〖急性毒性数据〗
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 650 uL/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 3/23/1973
  • 【测试类型】 LCLo - Lowest published lethal concentration
  • 【接触途径】 Inhalation
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 500 ppm/4H
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 300 mg/kg
  • 【毒性作用】 Sense Organs and Special Senses (Eye) - ptosis Behavioral - convulsions or effect on seizure threshold Gastrointestinal - alteration in gastric secretion
  • 【参考】 GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 24(4),56,1980
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Administration onto the skin
  • 【测试物种】 Rodent - rabbit
  • 【剂量/时间】 1010 uL/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951
  • 〖其他多剂量毒性数据〗
  • 【测试类型】 TCLo - Lowest published toxic concentration
  • 【接触途径】 Inhalation
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 38500 ug/m3/9W-I
  • 【毒性作用】 Brain and Coverings - recordings from specific areas of CNS Cardiac - EKG changes not diagnostic of specified effects Endocrine - other changes
  • 【参考】 GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 24(4),56,1980
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Intraperitoneal
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 3900 mg/kg/13W-I
  • 【毒性作用】 Behavioral - ataxia Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - body temperature decrease
  • 【参考】 FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,343,1992
  • 【测试类型】 TCLo - Lowest published toxic concentration
  • 【接触途径】 Inhalation
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 38500 ug/m3/9W-I
  • 【毒性作用】 Brain and Coverings - recordings from specific areas of CNS Cardiac - EKG changes not diagnostic of specified effects Related to Chronic Data - death
  • 【参考】 GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 24(4),56,1980
    〖致突变数据〗
  • 【测试类型】 Micronucleus testTEST SYSTEM : Rodent - mouse Lymphocyte
  • 【剂量/时间】 18 mg/L
  • 【参考】 MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 4,381,1989
  • 【测试类型】 Cytogenetic analysisTEST SYSTEM : Rodent - mouse Lymphocyte
  • 【剂量/时间】 15 mg/L
  • 【参考】 MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 4,381,1989
  • ◇◇◇综述◇◇◇
  • TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 11,141,1975
  • ◇◇◇NIOSH 标准发展和监测数据◇◇◇
  • 【NIOSH 职业性接触鉴定数据】 NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1326 No. of Facilities: 63 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 1845 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1326 No. of Facilities: 107 (estimated) No. of Industries: 4 No. of Occupations: 11 No. of Employees: 2370 (estimated) No. of Female Employees: 354 (estimated)
  • ◇◇◇在美国的情况◇◇◇
  • EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 47,26992,82 EPA TSCA Section 8(d) unpublished health/safety studies EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
  • ◇◇◇全部数据完毕◇◇◇
 
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