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128-37-0

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摘 要:128-37-0, RTECS NUMBER : GO7875000 CHEMICAL NAME : p-Cresol, 2,6-di-tert-butyl- CAS REGISTRY NUMBER
    ◇◇◇化学鉴别信息◇◇◇
  • 【RTECS 编号】 GO7875000
  • 【化学名】 p-Cresol, 2,6-di-tert-butyl-
  • 【CAS 登记号】 128-37-0OTHER CAS REGISTRY NOS. : 58500-82-6
  • 【上次更新时间】 199712
  • 【引用数据项】 79
  • 【分子式】 C15-H24-O
  • 【分子量】 220.39
  • 【维斯韦塞(氏)线的符号】 1X1&1&R BQ E1 CX1&1&1
  • 【化合物描述】 Tumorigen Mutagen Reproductive Effector Human Primary Irritant
  • 【别名】 * Advastab 401 * Agidol * Agidol 1 * Alkofen BP * Antioxidant DBPC * Antioxidant 4 * Antioxidant 29 * Antioxidant 30 * Antioxidant 4K * Antioxidant KB * Antrancine 8 * AO 29 * AO 4K * BHT * BHT (food grade) * 2,6-Bis(1,1-dimethylethyl)-4-methylphenol * BUKS * Butylated hydroxytoluene * Butylhydroxytoluene * Butylohydroksytoluenu * CAO 1 * CAO 3 * Catalin cao-3 * Chemanox 11 * Dalpac * DBMP * DBPC * DBPC (technical grade) * Deenax * Dibunol * Dibutylated hydroxytoluene * 2,6-Di-tert-butyl-p-cresol * 2,6-Di-terc.butyl-p-kresol * 2,6-Di-tert-butyl-1-hydroxy-4-methylbenzene * 3,5-Di-tert-butyl-4-hydroxytoluene * 2,6-Di-tert-butyl-p-methylphenol * 2,6-Di-tert-butyl-4-methylphenol * 4-Hydroxy-3,5-di-tert-butyltoluene * Impruvol * Ionol * Ionol 1 * Ionol (antioxidant) * Ionol CP * Ionole * Kerabit * 4-Methyl-2,6-di-terc. butylfenol * Methyldi-tert-butylphenol * 4-Methyl-2,6-di-tert-butylphenol * NCI-C03598 * Nocrac 200 * Nonox TBC * P 21 * Parabar 441 * Paranox 441 * Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl- * Stavox * Sumilizer BHT * Sustane BHT * Swanox BHT * Tenamene 3 * Tenox BHT * Topanol * Topanol O * Topanol OC * Toxolan P * Vanlube PC * Vanlube PCX * Vianol * Vulkanox KB
  • ◇◇◇卫生公害数据◇◇◇
    〖皮肤/眼睛刺激数据〗
  • 【测试类型】 Standard Draize test
  • 【接触途径】 Administration onto the skin
  • 【测试物种】 Human
  • 【剂量/时间】 500 mg/48HREACTION SEVERITY : Mild
  • 【参考】 AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 5,311,1952
  • 【测试类型】 Standard Draize test
  • 【接触途径】 Administration onto the skin
  • 【测试物种】 Rodent - rabbit
  • 【剂量/时间】 500 mg/48HREACTION SEVERITY : Moderate
  • 【参考】 AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 5,311,1952
  • 【测试类型】 Standard Draize test
  • 【接触途径】 Administration into the eye
  • 【测试物种】 Rodent - rabbit
  • 【剂量/时间】 100 mg/24HREACTION SEVERITY : Moderate
  • 【参考】 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,229,1986
    〖急性毒性数据〗
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Human - woman
  • 【剂量/时间】 80 mg/kg
  • 【毒性作用】 Behavioral - coma Gastrointestinal - gastritis Gastrointestinal - nausea or vomiting
  • 【参考】 NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 314,648,1986
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 890 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957- Volume(issue)/page/year: 24,253,1977
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 650 mg/kg
  • 【毒性作用】 Behavioral - tremor Lungs, Thorax, or Respiration - chronic pulmonary edema
  • 【参考】 SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949- Volume(issue)/page/year: 36(1-4),10,1989
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Intraperitoneal
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 138 mg/kg
  • 【毒性作用】 Lungs, Thorax, or Respiration - chronic pulmonary edema Lungs, Thorax, or Respiration - other changes Blood - hemorrhage
  • 【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 61,475,1981
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Intravenous
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 180 mg/kg
  • 【毒性作用】 Behavioral - sleep
  • 【参考】 JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,1350,1980
  • 【测试类型】 LDLo - Lowest published lethal dose
  • 【接触途径】 Oral
  • 【测试物种】 Mammal - cat
  • 【剂量/时间】 940 mg/kg
  • 【毒性作用】 Gastrointestinal - hypermotility, diarrhea Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
  • 【参考】 AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 11,93,1955
  • 【测试类型】 LDLo - Lowest published lethal dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rabbit
  • 【剂量/时间】 2100 mg/kg
  • 【毒性作用】 Gastrointestinal - hypermotility, diarrhea Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
  • 【参考】 AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 11,93,1955
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - guinea pig
  • 【剂量/时间】 10700 mg/kg
  • 【毒性作用】 Gastrointestinal - hypermotility, diarrhea Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
  • 【参考】 AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 11,93,1955
  • 〖其他多剂量毒性数据〗
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 109 gm/kg/2Y-C
  • 【毒性作用】 Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count
  • 【参考】 FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 19,147,1981
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 27 gm/kg/90D-C
  • 【毒性作用】 Liver - changes in liver weight Endocrine - evidence of thyroid hyperfunction Endocrine - changes in thyroid weight
  • 【参考】 TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 10,239,1982
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 37800 mg/kg/6W-C
  • 【毒性作用】 Liver - changes in liver weight Endocrine - changes in adrenal weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
  • 【参考】 AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86. Volume(issue)/page/year: 39,353,1961
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 5600 mg/kg/16W-C
  • 【毒性作用】 Liver - changes in liver weight Kidney, Ureter, Bladder - other changes in urine composition
  • 【参考】 FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 3,433,1965
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 275 mg/kg/26W-C
  • 【毒性作用】 Liver - changes in liver weight Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain
  • 【参考】 AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86. Volume(issue)/page/year: 37,533,1959
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 112 gm/kg/80W-C
  • 【毒性作用】 Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Metabolism (Intermediary) - other proteins
  • 【参考】 TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 7,289,1977
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 5040 mg/kg/7D-C
  • 【毒性作用】 Liver - changes in liver weight Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
  • 【参考】 APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 49,14,1981
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 13500 mg/kg/18D-I
  • 【毒性作用】 Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
  • 【参考】 FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 3,417,1965
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 48600 mg/kg/30D-C
  • 【毒性作用】 Lungs, Thorax, or Respiration - changes in lung weight Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
  • 【参考】 FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 30,89,1992
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Administration onto the skin
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 5 gm/kg/4W-I
  • 【毒性作用】 Lungs, Thorax, or Respiration - changes in lung weight Related to Chronic Data - death
  • 【参考】 TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 34,99,1986
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Primate - monkey
  • 【剂量/时间】 14 gm/kg/4W-I
  • 【毒性作用】 Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
  • 【参考】 FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 10,769,1972
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - hamster
  • 【剂量/时间】 1596 mg/kg/14D-C
  • 【毒性作用】 Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
  • 【参考】 FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 34,595,1996
  • 〖致肿瘤数据数据〗
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 134 gm/kg/32W-C
  • 【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Tumorigenic - cells (cultured) transformed
  • 【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 4,895,1983
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 435 mg/kg/69W-C
  • 【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors
  • 【参考】 FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,367,1974
  • 【测试类型】 TD - Toxic dose (other than lowest)
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 247 gm/kg/3Y-C
  • 【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Liver - tumors
  • 【参考】 FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 24,1,1986
  • 【测试类型】 TD - Toxic dose (other than lowest)
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 247 gm/kg/3Y-C
  • 【毒性作用】 Tumorigenic - neoplastic by RTECS criteria Reproductive - Tumorigenic effects - ovarian tumors
  • 【参考】 FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 24,1,1986
  • 【测试类型】 TD - Toxic dose (other than lowest)
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 1423 mg/kg/43W-C
  • 【毒性作用】 Tumorigenic - neoplastic by RTECS criteria Liver - tumors
  • 【参考】 TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 38,151,1986
  • 【测试类型】 TD - Toxic dose (other than lowest)
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 247 gm/kg
  • 【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
  • 【参考】 FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 24,1121,1986
  • 【测试类型】 TD - Toxic dose (other than lowest)
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 963 gm/kg
  • 【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors
  • 【参考】 FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 24,1071,1986
  • 〖繁殖数据〗
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - ratDOSE : 6 gm/kgSEX/DURATION : male 13 week(s) pre-mating female 13 week(s) pre-mating - 3 week(s) post-birth
  • 【毒性作用】 Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
  • 【参考】 FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 24,1,1986
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - ratDOSE : 18 gm/kgSEX/DURATION : male 2 week(s) pre-mating female 2 week(s) pre-mating - 3 week(s) post-birth
  • 【毒性作用】 Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral
  • 【参考】 FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 19,153,1981
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - ratDOSE : 9 gm/kgSEX/DURATION : male 2 week(s) pre-mating female 2 week(s) pre-mating - 3 week(s) post-birth
  • 【毒性作用】 Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
  • 【参考】 FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 19,153,1981
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - ratDOSE : 35 gm/kgSEX/DURATION : male 10 week(s) pre-mating
  • 【毒性作用】 Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
  • 【参考】 ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 8,357,1986
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - mouseDOSE : 43800 mg/kgSEX/DURATION : female 52 day(s) pre-mating female 1-21 day(s) after conception
  • 【毒性作用】 Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
  • 【参考】 FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 3,371,1965
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - mouseDOSE : 12600 mg/kgSEX/DURATION : female 1-21 day(s) after conception
  • 【毒性作用】 Reproductive - Effects on Newborn - behavioral
  • 【参考】 FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 31,596,1972
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - mouseDOSE : 1200 mg/kgSEX/DURATION : female 9 day(s) after conception
  • 【毒性作用】 Reproductive - Specific Developmental Abnormalities - musculoskeletal system
  • 【参考】 TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 1949/50- Volume(issue)/page/year: 28(2),45,1977
    〖致突变数据〗
  • 【测试类型】 DNA inhibitionTEST SYSTEM : Human HeLa cell
  • 【剂量/时间】 500 umol/L
  • 【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 13,2389,1992
  • 【测试类型】 DNA inhibitionTEST SYSTEM : Human Lymphocyte
  • 【剂量/时间】 20 umol/L
  • 【参考】 BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 80,963,1978
  • 【测试类型】 DNA damage
  • 【接触途径】 OralTEST SYSTEM : Rodent - rat
  • 【剂量/时间】 1400 mg/kg
  • 【参考】 FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 25,603,1987
  • 【测试类型】 Unscheduled DNA synthesis
  • 【接触途径】 OralTEST SYSTEM : Rodent - rat
  • 【剂量/时间】 16800 mg/kg/4W (Continuous)
  • 【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 99,37,1989
  • 【测试类型】 Unscheduled DNA synthesisTEST SYSTEM : Rodent - rat Liver
  • 【剂量/时间】 100 pmol/L
  • 【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,1547,1984
  • 【测试类型】 Unscheduled DNA synthesis
  • 【接触途径】 IntraperitonealTEST SYSTEM : Rodent - rat
  • 【剂量/时间】 1200 mg/kg/3D (Continuous)
  • 【参考】 DANKAS Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1933- Volume(issue)/page/year: 287,371,1986
  • 【测试类型】 Dominant lethal test
  • 【接触途径】 OralTEST SYSTEM : Rodent - rat
  • 【剂量/时间】 5460 mg/kg/10W (Continuous)
  • 【参考】 ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 8,357,1986
  • 【测试类型】 Mutation in microorganismsTEST SYSTEM : Rodent - mouse Lymphocyte
  • 【剂量/时间】 6 mg/L
  • 【参考】 EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 11,91,1988
  • 【测试类型】 Mutation test systems - not otherwise specified
  • 【接触途径】 OralTEST SYSTEM : Rodent - mouse
  • 【剂量/时间】 500 mg/kg
  • 【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 343,157,1995
  • 【测试类型】 DNA inhibition
  • 【接触途径】 IntraperitonealTEST SYSTEM : Rodent - mouse
  • 【剂量/时间】 250 mg/kg
  • 【参考】 CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 19,279,1977
  • 【测试类型】 Dominant lethal test
  • 【接触途径】 OralTEST SYSTEM : Rodent - mouse
  • 【剂量/时间】 12 gm/kg/10W (Continuous)
  • 【参考】 NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB278-026
  • 【测试类型】 Mutation in mammalian somatic cellsTEST SYSTEM : Rodent - mouse Lymphocyte
  • 【剂量/时间】 6 mg/L
  • 【参考】 EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 11,91,1988
  • 【测试类型】 Sperm Morphology
  • 【接触途径】 IntraperitonealTEST SYSTEM : Rodent - mouse
  • 【剂量/时间】 350 mg/kg/5D (Intermittent)
  • 【参考】 CMMUAO Chemical Mutagens. Principles and Methods for Their Detection. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1971- Volume(issue)/page/year: 5,257,1978
  • 【测试类型】 Cytogenetic analysisTEST SYSTEM : Rodent - hamster Ovary
  • 【剂量/时间】 100 ug/L
  • 【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 345,73,1995
  • ◇◇◇综述◇◇◇
  • ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 10 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,161,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,161,1986 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 35,89,1976
  • ◇◇◇职业接触限量◇◇◇
  • OEL-AUSTRALIA:TWA 10 mg/m3 JAN 1993 OEL-BELGIUM:TWA 10 mg/m3 JAN 1993 OEL-FINLAND:TWA 10 mg/m3;STEL 20 mg/m3;Skin JAN 1993 OEL-FRANCE:TWA 10 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 10 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 10 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 10 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
  • ◇◇◇NIOSH 标准发展和监测数据◇◇◇
    NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 2,6-DI-t-BUTYL-p-CRESOL-air:10H TWA 10 mg/m3
  • 【参考】 NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992
  • 【NIOSH 职业性接触鉴定数据】 NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83383 No. of Facilities: 1526 (estimated) No. of Industries: 32 No. of Occupations: 39 No. of Employees: 28860 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83383 No. of Facilities: 27242 (estimated) No. of Industries: 210 No. of Occupations: 154 No. of Employees: 591238 (estimated) No. of Female Employees: 163774 (estimated)
  • ◇◇◇在美国的情况◇◇◇
  • EPA GENETOX PROGRAM 1988, Positive: D melanogaster-whole sex chrom. loss EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; Mouse specific locus EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-reciprocal translocation EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; Sperm morphology-mouse EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA Section 8(d) unpublished health/safety studies EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9076 EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*. Volume(issue)/page/year: NCI-TR-150,79
  • ◇◇◇全部数据完毕◇◇◇
 
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