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50-06-6

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摘 要:50-06-6, RTECS NUMBER : CQ6825000 CHEMICAL NAME : Barbituric acid, 5-ethyl-5-phenyl- CAS REGISTRY NU
    ◇◇◇化学鉴别信息◇◇◇
  • 【RTECS 编号】 CQ6825000
  • 【化学名】 Barbituric acid, 5-ethyl-5-phenyl-
  • 【CAS 登记号】 50-06-6OTHER CAS REGISTRY NOS. : 11097-06-6
  • 【上次更新时间】 199710
  • 【引用数据项】 126
  • 【分子式】 C12-H12-N2-O3
  • 【分子量】 232.26
  • 【维斯韦塞(氏)线的符号】 T6VMVMV FHJ F2 FR
  • 【化合物描述】 Tumorigen Drug Mutagen Reproductive Effector Human
  • 【别名】 * Acido 5-fenil-5-etilbarbiturico * Adonal * Aephenal * Agrypnal * Amylofene * Aphenylbarbit * Aphenyletten * Austrominal * Barbenyl * Barbiphenyl * Barbipil * Barbita * Barbivis * Barbonal * Barbophen * Bialminal * Blu-phen * Cardenal * Cratecil * Dormiral * Doscalun * Duneryl * Eskabarb * 5-Ethyl-5-phenylbarbituric acid * 5-Ethyl-5-phenyl-2,4,6-(1H,3H,5H)pyrimidinetrione * Etilfen * Euneryl * Fenemal * Fenobarbital * Gardenal * Gardepanyl * Helional * Hysteps * Lepinal * Lepinaletten * Liquital * Lixophen * Lubergal * Lubrokal * Luminal * Lumofridetten * Luphenil * Luramin * Molinal * Neurobarb * Nirvonal * Noptil * Nova-pheno * Nunol * Parkotal * Pharmetten * Phenaemal * Phen-Bar * Phenemal * Phenobal * Phenobarbital * Phenobarbitone * Phenobarbituric acid * Phenobarbyl * Phenoluric * Phenolurio * Phenomet * Phenonyl * Phenoturic * Phenylethylbarbiturate * Phenyl-ethyl-barbituric acid * 5-Phenyl-5-ethylbarbituric acid * Phenylethylmalonylurea * Phenyletten * Phenyral * PHOB * 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-phenyl- * Sedabar * Seda-Tablinen * Sedicat * Sedizorin * Sedlyn * Sedofen * Sedonal * Sedonettes * Sedophen * Sevenal * SK-Phenobarbital * Spasepilin * Starifen * Starilettae * Stental * Stental extentabs * Teolaxin * Thenobarbital * Theoloxin * Theominal * Triabarb * Triphenatol * Versomnal * Zadoletten * Zadonal
  • ◇◇◇卫生公害数据◇◇◇
    〖急性毒性数据〗
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Human - woman
  • 【剂量/时间】 46 mg/kg
  • 【毒性作用】 Behavioral - coma Lungs, Thorax, or Respiration - dyspnea
  • 【参考】 CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962- Volume(issue)/page/year: 24,678,1985
  • 【测试类型】 LDLo - Lowest published lethal dose
  • 【接触途径】 Oral
  • 【测试物种】 Human - woman
  • 【剂量/时间】 25272 ug/kg/13D-I
  • 【毒性作用】 Behavioral - coma Skin and Appendages - dermatitis, allergic (after systemic exposure) Nutritional and Gross Metabolic - body temperature increase
  • 【参考】 CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911- Volume(issue)/page/year: 33,635,1935
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Human - child
  • 【剂量/时间】 10 mg/kg
  • 【毒性作用】 Behavioral - somnolence (general depressed activity) Behavioral - ataxia
  • 【参考】 AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960- Volume(issue)/page/year: 130,507,1976
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Human
  • 【剂量/时间】 18 mg/kg
  • 【毒性作用】 Lungs, Thorax, or Respiration - other changes Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - body temperature increase
  • 【参考】 JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 116,700,1941
  • 【测试类型】 LDLo - Lowest published lethal dose
  • 【接触途径】 Oral
  • 【测试物种】 Human - man
  • 【剂量/时间】 6485 ug/kg/2W-I
  • 【毒性作用】 Skin and Appendages - dermatitis, allergic (after systemic exposure) Nutritional and Gross Metabolic - body temperature increase
  • 【参考】 AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 13,1243,1940
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Intramuscular
  • 【测试物种】 Human - infant
  • 【剂量/时间】 50 mg/kg
  • 【毒性作用】 Behavioral - coma
  • 【参考】 PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034, Evanston, IL 60204) V.1- 1948- Volume(issue)/page/year: 77,848,1986
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 162 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Intraperitoneal
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 151 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,477,1980
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Subcutaneous
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 200 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 152,341,1930
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Intravenous
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 209 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 40,211,1978
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Rectal
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 284 mg/kg
  • 【毒性作用】 Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - body temperature decrease Behavioral - general anesthetic
  • 【参考】 AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 46,395,1967
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 137 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 10,41,1976
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Intraperitoneal
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 116 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 53(4),19,1990
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Subcutaneous
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 228 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,477,1980
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Intravenous
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 218 mg/kg
  • 【毒性作用】 Peripheral Nerve and Sensation - local anesthetic
  • 【参考】 AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 191,405,1971
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Intramuscular
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 175 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 23,2215,1981
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Oral
  • 【测试物种】 Mammal - dog
  • 【剂量/时间】 150 mg/kg
  • 【毒性作用】 Behavioral - somnolence (general depressed activity)
  • 【参考】 SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 85,305,1955
  • 【测试类型】 LDLo - Lowest published lethal dose
  • 【接触途径】 Subcutaneous
  • 【测试物种】 Mammal - dog
  • 【剂量/时间】 150 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
  • 【测试类型】 LDLo - Lowest published lethal dose
  • 【接触途径】 Oral
  • 【测试物种】 Mammal - cat
  • 【剂量/时间】 125 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
  • 【测试类型】 LDLo - Lowest published lethal dose
  • 【接触途径】 Subcutaneous
  • 【测试物种】 Mammal - cat
  • 【剂量/时间】 125 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rabbit
  • 【剂量/时间】 185 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 NUPOBT Neuropatologia Polska. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1963- Volume(issue)/page/year: 15,545,1977
  • 【测试类型】 LDLo - Lowest published lethal dose
  • 【接触途径】 Intraperitoneal
  • 【测试物种】 Rodent - rabbit
  • 【剂量/时间】 150 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 44,325,1932
  • 【测试类型】 LDLo - Lowest published lethal dose
  • 【接触途径】 Subcutaneous
  • 【测试物种】 Rodent - rabbit
  • 【剂量/时间】 150 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 45,243,1923
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Intravenous
  • 【测试物种】 Rodent - rabbit
  • 【剂量/时间】 187 mg/kg
  • 【毒性作用】 Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation
  • 【参考】 ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,1168,1983
  • 【测试类型】 LD50 - Lethal dose, 50 percent kill
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - guinea pig
  • 【剂量/时间】 130 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 91,437,1952
  • 【测试类型】 LDLo - Lowest published lethal dose
  • 【接触途径】 Subcutaneous
  • 【测试物种】 Amphibian - frog
  • 【剂量/时间】 500 mg/kg
  • 【毒性作用】 Details of toxic effects not reported other than lethal dose value
  • 【参考】 HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
  • 〖其他多剂量毒性数据〗
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Intraperitoneal
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 240 mg/kg/3D-I
  • 【毒性作用】 Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
  • 【参考】 ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 40,239,1990
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Unreported
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 1400 mg/kg/2W-I
  • 【毒性作用】 Liver - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
  • 【参考】 PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987- Volume(issue)/page/year: 73(Suppl 2),113,1993
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 28 gm/kg/40W-C
  • 【毒性作用】 Liver - other changes Liver - changes in liver weight
  • 【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 96,494,1988
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Intraperitoneal
  • 【测试物种】 Bird - quail
  • 【剂量/时间】 750 mg/kg/5D-I
  • 【毒性作用】 Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
  • 【参考】 JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 15,93,1985
  • 〖致肿瘤数据数据〗
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 7560 mg/kg/36W-C
  • 【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Tumorigenic - cells (cultured) transformed
  • 【参考】 GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP. Volume(issue)/page/year: 69,679,1978
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 22 gm/kg/1Y-C
  • 【毒性作用】 Tumorigenic - neoplastic by RTECS criteria Liver - tumors
  • 【参考】 JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 51,1349,1973
  • 【测试类型】 TD - Toxic dose (other than lowest)
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 38 gm/kg/90W-C
  • 【毒性作用】 Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
  • 【参考】 FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 11,433,1973
  • 【测试类型】 TD - Toxic dose (other than lowest)
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 4200 mg/kg/20W-C
  • 【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Tumorigenic - cells (cultured) transformed
  • 【参考】 CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 5,139,1978
  • 【测试类型】 TD - Toxic dose (other than lowest)
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 30 mg/kg/78W-C
  • 【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Endocrine - thyroid tumors
  • 【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 10,183,1989
  • 【测试类型】 TD - Toxic dose (other than lowest)
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 3990 mg/kg/19W-C
  • 【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Endocrine - thyroid tumors Tumorigenic - cells (cultured) transformed
  • 【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 4,935,1983
  • 【测试类型】 TD - Toxic dose (other than lowest)
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 2520 mg/kg/12W-C
  • 【毒性作用】 Tumorigenic - neoplastic by RTECS criteria Endocrine - thyroid tumors Tumorigenic - cells (cultured) transformed
  • 【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 4,935,1983
  • 【测试类型】 TD - Toxic dose (other than lowest)
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rat
  • 【剂量/时间】 2100 mg/kg/12W-C
  • 【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Endocrine - thyroid tumors Tumorigenic - cells (cultured) transformed
  • 【参考】 IGAYAY Igaku No Ayumi. Progress in Medicine. (Ishiyaku Shuppan K.K., 1-7-10, Honkomagom, Bunkyo-ku, Tokyo, Japan) V.1- 1946- Volume(issue)/page/year: 123,1069,1982
  • 【测试类型】 TD - Toxic dose (other than lowest)
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - mouse
  • 【剂量/时间】 5200 mg/kg/52W-C
  • 【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
  • 【参考】 53HJAC "Mouse Liver Neoplasia: Current Perspectives," Popp, J.A., ed., New York, Hemisphere Pub. Corp., 1984 Volume(issue)/page/year: -,145,1984
  • 〖繁殖数据〗
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Human - womanDOSE : 151 mg/kgSEX/DURATION : female 27-39 week(s) after conception
  • 【毒性作用】 Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - drug dependence
  • 【参考】 JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 80,190,1972
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Human - womanDOSE : 3600 ug/kgSEX/DURATION : female 26 week(s) after conception
  • 【毒性作用】 Reproductive - Specific Developmental Abnormalities - hepatobiliary system Reproductive - Effects on Newborn - biochemical and metabolic
  • 【参考】 AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 159,1491,1988
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Unreported
  • 【测试物种】 Human - womanDOSE : 491 mg/kgSEX/DURATION : female 1-39 week(s) after conception
  • 【毒性作用】 Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - respiratory system
  • 【参考】 LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,839,1972
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Unreported
  • 【测试物种】 Human - womanDOSE : 907 mg/kgSEX/DURATION : female 1-36 week(s) after conception
  • 【毒性作用】 Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - other postnatal measures or effects
  • 【参考】 LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,839,1972
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Unreported
  • 【测试物种】 Human - womanDOSE : 529 mg/kgSEX/DURATION : female 1-42 week(s) after conception
  • 【毒性作用】 Reproductive - Specific Developmental Abnormalities - gastrointestinal system
  • 【参考】 LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,839,1972
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Unreported
  • 【测试物种】 Human - womanDOSE : 454 mg/kgSEX/DURATION : female 1-36 week(s) after conception
  • 【毒性作用】 Reproductive - Specific Developmental Abnormalities - Central Nervous System
  • 【参考】 LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,839,1972
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - ratDOSE : 880 mg/kgSEX/DURATION : female 7-17 day(s) after conception
  • 【毒性作用】 Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow)
  • 【参考】 SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 19,178,1979
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - ratDOSE : 440 mg/kgSEX/DURATION : female 7-17 day(s) after conception
  • 【毒性作用】 Reproductive - Specific Developmental Abnormalities - musculoskeletal system
  • 【参考】 TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 20,157,1979
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - ratDOSE : 300 mg/kgSEX/DURATION : female 4-8 day(s) after conception
  • 【毒性作用】 Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - abortion
  • 【参考】 FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 22,735,1971
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - ratDOSE : 320 mg/kgSEX/DURATION : female 7-10 day(s) after conception
  • 【毒性作用】 Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - behavioral
  • 【参考】 JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 227,274,1983
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - ratDOSE : 800 mg/kgSEX/DURATION : female 6-13 day(s) after conception
  • 【毒性作用】 Reproductive - Effects on Embryo or Fetus - fetal death
  • 【参考】 TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 24,1,1981
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - ratDOSE : 280 mg/kgSEX/DURATION : lactating female 1-7 day(s) post-birth
  • 【毒性作用】 Reproductive - Effects on Newborn - biochemical and metabolic
  • 【参考】 SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 211,719,1981
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - ratDOSE : 60 mg/kgSEX/DURATION : female 7-18 day(s) after conception
  • 【毒性作用】 Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
  • 【参考】 JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 227,274,1983
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Intraperitoneal
  • 【测试物种】 Rodent - ratDOSE : 1 gm/kgSEX/DURATION : female 1-20 day(s) after conception
  • 【毒性作用】 Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
  • 【参考】 AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 107,1250,1970
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Intraperitoneal
  • 【测试物种】 Rodent - ratDOSE : 180 mg/kgSEX/DURATION : female 19-21 day(s) after conception
  • 【毒性作用】 Reproductive - Effects on Embryo or Fetus - other effects to embryo
  • 【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 73,457,1984
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Subcutaneous
  • 【测试物种】 Rodent - ratDOSE : 320 mg/kgSEX/DURATION : multigenerations
  • 【毒性作用】 Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
  • 【参考】 PPHAD4 Pediatric Pharmacology. (New York, NY) V.1-5, 1980-86. For publisher information, see DPTHDL. Volume(issue)/page/year: 1,55,1980
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Subcutaneous
  • 【测试物种】 Rodent - ratDOSE : 750 mg/kgSEX/DURATION : female 1 day(s) pre-mating
  • 【毒性作用】 Reproductive - Fertility - other measures of fertility
  • 【参考】 PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 139,741,1972
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Subcutaneous
  • 【测试物种】 Rodent - ratDOSE : 20 mg/kgSEX/DURATION : female 5-8 day(s) after conception
  • 【毒性作用】 Reproductive - Effects on Newborn - behavioral
  • 【参考】 TJEMAO Tohoku Journal of Experimental Medicine. (Maruzen Co. Ltd., Export Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan) V.1- 1920- Volume(issue)/page/year: 89,265,1966
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Subcutaneous
  • 【测试物种】 Rodent - ratDOSE : 320 mg/kgSEX/DURATION : female 12-19 day(s) after conception
  • 【毒性作用】 Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - physical Reproductive - Effects on Newborn - delayed effects
  • 【参考】 EXMDA4 International Congress Series--Excerpta Medica. (Excerpta Medica, Inc., POB 3085, Princeton, NJ 08540) No.1- 1952- Volume(issue)/page/year: (551),250,1981
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Subcutaneous
  • 【测试物种】 Rodent - ratDOSE : 160 mg/kgSEX/DURATION : female 17-20 day(s) after conception
  • 【毒性作用】 Reproductive - Effects on Newborn - physical Reproductive - Effects on Newborn - delayed effects
  • 【参考】 PPHAD4 Pediatric Pharmacology. (New York, NY) V.1-5, 1980-86. For publisher information, see DPTHDL. Volume(issue)/page/year: 2,85,1982
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Intramuscular
  • 【测试物种】 Rodent - ratDOSE : 200 mg/kgSEX/DURATION : female 18-20 day(s) after conception lactating female 15 day(s) post-birth
  • 【毒性作用】 Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Specific Developmental Abnormalities - Central Nervous System
  • 【参考】 TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 26,21,1982
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Unreported
  • 【测试物种】 Rodent - ratDOSE : 40 mg/kgSEX/DURATION : female 17 day(s) after conception
  • 【毒性作用】 Reproductive - Effects on Newborn - other postnatal measures or effects
  • 【参考】 SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 216,640,1982
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Multiple routes
  • 【测试物种】 Rodent - ratDOSE : 340 mg/kgSEX/DURATION : female 20-22 day(s) after conception lactating female 7 day(s) post-birth
  • 【毒性作用】 Reproductive - Effects on Newborn - other postnatal measures or effects
  • 【参考】 AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 187,155,1970
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - mouseDOSE : 210 mg/kgSEX/DURATION : male 5 day(s) pre-mating
  • 【毒性作用】 Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
  • 【参考】 FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,335,1983
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - mouseDOSE : 400 mg/kgSEX/DURATION : female 6-15 day(s) after conception
  • 【毒性作用】 Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
  • 【参考】 TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 6,323,1976
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - mouseDOSE : 33 mg/kgSEX/DURATION : female 9-19 day(s) after conception
  • 【毒性作用】 Reproductive - Effects on Newborn - physical
  • 【参考】 IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013, Israel) V.1- 1965- Volume(issue)/page/year: 14,929,1978
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - mouseDOSE : 3600 mg/kgSEX/DURATION : female 9-18 day(s) after conception
  • 【毒性作用】 Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral
  • 【参考】 PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 68,301,1980
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - mouseDOSE : 1080 mg/kgSEX/DURATION : female 16-18 day(s) after conception
  • 【毒性作用】 Reproductive - Specific Developmental Abnormalities - Central Nervous System
  • 【参考】 ACATA5 Acta Anatomica. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1945- Volume(issue)/page/year: 108,370,1980
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - mouseDOSE : 63 gm/kgSEX/DURATION : female 1-21 day(s) after conception
  • 【毒性作用】 Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)
  • 【参考】 TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 25(1),15A,1982
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Intraperitoneal
  • 【测试物种】 Rodent - mouseDOSE : 150 mg/kgSEX/DURATION : female 8-10 day(s) after conception
  • 【毒性作用】 Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
  • 【参考】 TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 1,393,1968
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Intraperitoneal
  • 【测试物种】 Rodent - mouseDOSE : 560 mg/kgSEX/DURATION : female 8-14 day(s) after conception
  • 【毒性作用】 Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
  • 【参考】 ACATA5 Acta Anatomica. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1945- Volume(issue)/page/year: 58,217,1964
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Intraperitoneal
  • 【测试物种】 Rodent - mouseDOSE : 300 mg/kgSEX/DURATION : female 17-19 day(s) after conception
  • 【毒性作用】 Reproductive - Effects on Newborn - biochemical and metabolic
  • 【参考】 AJANA2 American Journal of Anatomy. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1-192, 1901-91. Volume(issue)/page/year: 138,449,1973
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Subcutaneous
  • 【测试物种】 Rodent - mouseDOSE : 280 mg/kgSEX/DURATION : female 15-21 day(s) after conception
  • 【毒性作用】 Reproductive - Effects on Newborn - behavioral
  • 【参考】 DEPBA5 Developmental Psychobiology. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1968- Volume(issue)/page/year: 8,305,1975
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Parenteral
  • 【测试物种】 Rodent - mouseDOSE : 60 ug/kgSEX/DURATION : female 1 day(s) pre-mating
  • 【毒性作用】 Reproductive - Maternal Effects - uterus, cervix, vagina
  • 【参考】 PPHAD4 Pediatric Pharmacology. (New York, NY) V.1-5, 1980-86. For publisher information, see DPTHDL. Volume(issue)/page/year: 5,157,1985
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Unreported
  • 【测试物种】 Rodent - mouseDOSE : 40 mg/kgSEX/DURATION : female 1 day(s) pre-mating
  • 【毒性作用】 Reproductive - Fertility - other measures of fertility
  • 【参考】 FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 12,346,1961
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rabbitDOSE : 450 mg/kgSEX/DURATION : female 8-16 day(s) after conception
  • 【毒性作用】 Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
  • 【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 10,244,1967
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rabbitDOSE : 450 mg/kgSEX/DURATION : female 8-16 day(s) after conception
  • 【毒性作用】 Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
  • 【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 10,244,1967
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Oral
  • 【测试物种】 Rodent - rabbitDOSE : 536 mg/kgSEX/DURATION : female 3-31 day(s) after conception
  • 【毒性作用】 Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Effects on Newborn - biochemical and metabolic
  • 【参考】 FOMOAJ Folia Morphologica (Warsaw). (Panstwowy Zaklad Wydawnictw Lekarskich, ul. Dluga 38-40, 00 238 Warsaw, Poland) V.1- 1929- Volume(issue)/page/year: 38,259,1979
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Intramuscular
  • 【测试物种】 Rodent - rabbitDOSE : 175 gm/kgSEX/DURATION : female 20-27 day(s) after conception
  • 【毒性作用】 Reproductive - Effects on Newborn - biochemical and metabolic
  • 【参考】 AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 124,529,1976
  • 【测试类型】 TDLo - Lowest published toxic dose
  • 【接触途径】 Intraperitoneal
  • 【测试物种】 Rodent - hamsterDOSE : 140 mg/kgSEX/DURATION : female 1 day(s) pre-mating
  • 【毒性作用】 Reproductive - Fertility - other measures of fertility
  • 【参考】 PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 162,170,1979
    〖致突变数据〗
  • 【测试类型】 Mutation in microorganismsTEST SYSTEM : Bacteria - Salmonella typhimurium
  • 【剂量/时间】 100 ug/plate
  • 【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 147,255,1985
  • 【测试类型】 Mutation in microorganismsTEST SYSTEM : Bacteria - Salmonella typhimurium
  • 【剂量/时间】 500 ug/plate
  • 【参考】 PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 5,187,1985
  • 【测试类型】 Mutation test systems - not otherwise specifiedTEST SYSTEM : Bacteria - Salmonella typhimurium
  • 【剂量/时间】 1 gm/L
  • 【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 192,239,1987
  • 【测试类型】 Sex chromosome loss and nondisjunction
  • 【接触途径】 OralTEST SYSTEM : Insect - Drosophila melanogaster
  • 【剂量/时间】 2 mg/6D
  • 【参考】 SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year: 11,718,1975
  • 【测试类型】 Mutation in microorganismsTEST SYSTEM : Yeast - Saccharomyces cerevisiae
  • 【剂量/时间】 500 mg/L
  • 【参考】 PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 5,271,1985
  • 【测试类型】 Gene conversion and mitotic recombinationTEST SYSTEM : Yeast - Saccharomyces cerevisiae
  • 【剂量/时间】 500 mg/L
  • 【参考】 PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 5,271,1985
  • 【测试类型】 Sex chromosome loss and nondisjunctionTEST SYSTEM : Yeast - Saccharomyces cerevisiae
  • 【剂量/时间】 430 umol/L
  • 【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 144,67,1985
  • 【测试类型】 Cytogenetic analysisTEST SYSTEM : Human Leukocyte
  • 【剂量/时间】 400 mg/L/90M
  • 【参考】 CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D: Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher information, see CRASEV. Volume(issue)/page/year: 268,191,1969
  • 【测试类型】 Cytogenetic analysisTEST SYSTEM : Human Lymphocyte
  • 【剂量/时间】 10 mg/L
  • 【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 204,623,1988
  • 【测试类型】 Mutation in mammalian somatic cellsTEST SYSTEM : Human Lymphocyte
  • 【剂量/时间】 1 gm/L
  • 【参考】 PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 5,497,1985
  • 【测试类型】 Morphological transformation
  • 【接触途径】 OralTEST SYSTEM : Rodent - rat
  • 【剂量/时间】 1260 mg/kg/6W
  • 【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 9,387,1988
  • 【测试类型】 DNA damageTEST SYSTEM : Rodent - rat Liver
  • 【剂量/时间】 1 mmol/L
  • 【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 368,59,1996
  • 【测试类型】 Unscheduled DNA synthesis
  • 【接触途径】 OralTEST SYSTEM : Rodent - rat
  • 【剂量/时间】 4410 mg/kg/21W (Continuous)
  • 【参考】 CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 33,119,1986
  • 【测试类型】 Unscheduled DNA synthesisTEST SYSTEM : Rodent - rat Liver
  • 【剂量/时间】 100 pmol/L
  • 【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 6,811,1985
  • 【测试类型】 DNA inhibitionTEST SYSTEM : Rodent - rat Liver
  • 【剂量/时间】 1500 umol/L
  • 【参考】 JCROD7 Journal of Cancer Research and Clinical Oncology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.93- 1979- Volume(issue)/page/year: 116,259,1990
  • 【测试类型】 Phage inhibition capacity
  • 【接触途径】 IntraperitonealTEST SYSTEM : Rodent - rat
  • 【剂量/时间】 240 mg/kg/3D (Intermittent)
  • 【参考】 HPTLD9 Hepatology (Baltimore). (Williams & Wilkins Co., Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1981- Volume(issue)/page/year: 8,1051,1988
  • 【测试类型】 Mutation in microorganismsTEST SYSTEM : Rodent - mouse Lymphocyte
  • 【剂量/时间】 2 gm/L
  • 【参考】 PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 5,587,1985
  • 【测试类型】 Morphological transformationTEST SYSTEM : Rodent - mouse Embryo
  • 【剂量/时间】 667 mg/L
  • 【参考】 PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 5,639,1985
  • 【测试类型】 Unscheduled DNA synthesis
  • 【接触途径】 OralTEST SYSTEM : Rodent - mouse
  • 【剂量/时间】 400 mg/kg/4D (Continuous)
  • 【参考】 CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 48,43,1989
  • 【测试类型】 Cytogenetic analysis
  • 【接触途径】 OralTEST SYSTEM : Rodent - mouse
  • 【剂量/时间】 3332 ug/kg
  • 【参考】 IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 22,666,1984
  • 【测试类型】 Dominant lethal test
  • 【接触途径】 OralTEST SYSTEM : Rodent - mouse
  • 【剂量/时间】 210 mg/kg/5D (Continuous)
  • 【参考】 FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,335,1983
  • 【测试类型】 Mutation in mammalian somatic cellsTEST SYSTEM : Rodent - mouse Lymphocyte
  • 【剂量/时间】 500 mg/L
  • 【参考】 PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 5,587,1985
  • 【测试类型】 Morphological transformationTEST SYSTEM : Rodent - hamster Embryo
  • 【剂量/时间】 100 mg/L
  • 【参考】 PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 5,665,1985
  • 【测试类型】 Cytogenetic analysisTEST SYSTEM : Rodent - hamster Ovary
  • 【剂量/时间】 15 mmol/L
  • 【参考】 PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 5,433,1985
  • 【测试类型】 Cytogenetic analysisTEST SYSTEM : Rodent - hamster Lung
  • 【剂量/时间】 2 gm/L/48H
  • 【参考】 GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981
  • 【测试类型】 Cytogenetic analysisTEST SYSTEM : Rodent - hamster Liver
  • 【剂量/时间】 100 mg/L
  • 【参考】 PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 5,397,1985
  • 【测试类型】 Sister chromatid exchangeTEST SYSTEM : Rodent - hamster Ovary
  • 【剂量/时间】 15 mmol/L
  • 【参考】 PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 5,433,1985
  • 【测试类型】 Sister chromatid exchangeTEST SYSTEM : Rodent - hamster Lung
  • 【剂量/时间】 10 mg/L
  • 【参考】 BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 45,769,1982
  • ◇◇◇综述◇◇◇
  • IARC Cancer Review:Animal Sufficient Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,313,1987 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 13,157,1977 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,313,1987 TOXICOLOGY REVIEW DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. (ADIS Press International Inc., Suite B-30, Oxford Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047) V.1- 1971- Volume(issue)/page/year: 8,354,1974 TOXICOLOGY REVIEW PLMJAP Pahlavi Medical Journal. (Shiraz, Iran) V.1-9, 1970-78. Volume(issue)/page/year: 6,160,1975 TOXICOLOGY REVIEW AUHPAI Australian Journal of Hospital Pharmacy. (B.R. Miller, POB 125, Heidelberg, Vic., Australia) V.1- 1971- Volume(issue)/page/year: 4(1),5,1974 TOXICOLOGY REVIEW JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974 TOXICOLOGY REVIEW PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 19,472,1939 TOXICOLOGY REVIEW EPILAK Epilepsia (New York). (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) Ser.1-3: 1909-55; Ser.4: V.1- 1959- Volume(issue)/page/year: 16,159,1975 TOXICOLOGY REVIEW PRSMA4 Proceedings of the Royal Society of Medicine. (New York, NY) V.1-70, 1907-77. For publisher information, see JRSMD9. Volume(issue)/page/year: 63,48,1970 TOXICOLOGY REVIEW BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,442,1973 TOXICOLOGY REVIEW AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960- Volume(issue)/page/year: 131,1337,1977 TOXICOLOGY REVIEW NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 7,287,1986
  • ◇◇◇NIOSH 标准发展和监测数据◇◇◇
  • 【NIOSH 职业性接触鉴定数据】 NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84369 No. of Facilities: 3360 (estimated) No. of Industries: 4 No. of Occupations: 22 No. of Employees: 15081 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84369 No. of Facilities: 810 (estimated) No. of Industries: 4 No. of Occupations: 14 No. of Employees: 22924 (estimated) No. of Female Employees: 17005 (estimated)
  • ◇◇◇在美国的情况◇◇◇
  • EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Sperm morphology-mouse EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus EPA TSCA Section 8(d) unpublished health/safety studies EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
  • ◇◇◇全部数据完毕◇◇◇
 
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